2-{4-[14-(9H-fluoren-9-yl)-12-oxo-5,8,13-trioxa-2,11-diazatetradecanoyl]piperidino}ethyl 4-amino-5-chloro-2-methoxybenzoate

Base Information

Chemical Name:2-{4-[14-(9H-fluoren-9-yl)-12-oxo-5,8,13-trioxa-2,11-diazatetradecanoyl]piperidino}ethyl 4-amino-5-chloro-2-methoxybenzoate
CAS No.:868599-11-5
Molecular Formula:C₃₇H₄₅ClN₄O₈
Molecular Weight:709.239
Hs Code.:

Synonyms:2-{4-[14-(9H-fluoren-9-yl)-12-oxo-5,8,13-trioxa-2,11-diazatetradecanoyl]piperidino}ethyl 4-amino-5-chloro-2-methoxybenzoate

Suppliers and Price of 2-{4-[14-(9H-fluoren-9-yl)-12-oxo-5,8,13-trioxa-2,11-diazatetradecanoyl]piperidino}ethyl 4-amino-5-chloro-2-methoxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{4-[14-(9H-fluoren-9-yl)-12-oxo-5,8,13-trioxa-2,11-diazatetradecanoyl]piperidino}ethyl 4-amino-5-chloro-2-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{4-[14-(9H-fluoren-9-yl)-12-oxo-5,8,13-trioxa-2,11-diazatetradecanoyl]piperidino}ethyl 4-amino-5-chloro-2-methoxybenzoate

There total 4 articles about 2-{4-[14-(9H-fluoren-9-yl)-12-oxo-5,8,13-trioxa-2,11-diazatetradecanoyl]piperidino}ethyl 4-amino-5-chloro-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 868599-73-9
9H-fluoren-9-ylmethyl N-{2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate hydrochloride

: 1-[2-(4-amino-5-chloro-2-methoxy-benzoyloxy)-ethyl]-piperidine-4-carboxylic acid; compound with trifluoro-acetic acid

: 868599-11-5
2-{4-[14-(9H-fluoren-9-yl)-12-oxo-5,8,13-trioxa-2,11-diazatetradecanoyl]piperidino}ethyl 4-amino-5-chloro-2-methoxybenzoate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm050234z

Reference yield:

: 868599-06-8
tert-butyl 1-{2-[(4-amino-5-chloro-2-methoxybenzoyl)oxy]ethyl}piperidine-4-carboxylate

: 868599-11-5
2-{4-[14-(9H-fluoren-9-yl)-12-oxo-5,8,13-trioxa-2,11-diazatetradecanoyl]piperidino}ethyl 4-amino-5-chloro-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / CH₂Cl₂ / 24 h / 20 °C

2: 69 percent / HOBt; EDC; Et₃N / CH₂Cl₂ / 24 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane;
DOI:10.1021/jm050234z

Reference yield:

: 172679-60-6
4-amino-5-chloro-2-methoxybenzoic acid 2-bromoethyl ester

: 868599-11-5
2-{4-[14-(9H-fluoren-9-yl)-12-oxo-5,8,13-trioxa-2,11-diazatetradecanoyl]piperidino}ethyl 4-amino-5-chloro-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / ethyldiisopropylamine / dimethylformamide / 24 h / 40 - 50 °C

2: 74 percent / CH₂Cl₂ / 24 h / 20 °C

3: 69 percent / HOBt; EDC; Et₃N / CH₂Cl₂ / 24 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050234z