Technology Process of Dov-Val-Dil-Dap-4-(dihydrophosphoryloxy)phenethylamide
There total 9 articles about Dov-Val-Dil-Dap-4-(dihydrophosphoryloxy)phenethylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 1h;
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
for 1h;
DOI:10.1021/np1007334
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 16 h / 20 °C
2.1: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C
2.2: 0.5 h
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C
3.2: 6 h / 20 °C
4.1: tetrachloromethane; dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / -20 - 5 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h
With
tetrachloromethane; dmap; trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/np1007334
