Chemical Property of 2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt
Chemical Property:
- Appearance/Colour:WHITE POWDER
- Melting Point:287-290°C
- PSA：105.02000
- Density:1.59 g/cm3
- LogP:2.02120
- Storage Temp.:2-8°C
- Solubility.:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Water Solubility.:Soluble in water at 5mg/ml
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:2
- Exact Mass:293.96004060
- Heavy Atom Count:18
- Complexity:452
- Purity/Quality:
-
99%, *data from raw suppliers
4-Methylumbelliferyl Sulfate, Potassium Salt *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=O)OC2=C1C=CC(=C2)OS(=O)(=O)[O-].[K+]
-
Uses
Met-enkephalin analog found in opioid extracts of brain and adrenal chromaffin cells that is an artifact generated by trichloroacetic acid extraction. MUS is used as a fluorimetric substrate for arylsulphatase enzyme. Subsitution of the hydroxyl group of 4-Methylumbelliferyl sulfate potassium salt causes the excitation wavelength of the umbelliferone to shift to shorter values and also brings about a decrease in fluorescence. Fluorescence: max. Abs = 334 mm; max. Em. = 370 mm 4-Methylumbelliferyl sulfate potassium salt is a fluorometric substrate for the determination of sulfatase. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.
