[((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid

Base Information

• Chemical Name: [((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid
• CAS No.: 131506-22-4
• Molecular Formula: C₂₂H₃₀N₂O₅
• Molecular Weight: 402.491
• Mol file: 131506-22-4.mol

Synonyms:[((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid

Chemical Property of [((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid

There total 3 articles about [((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid ethyl ester (131506-08-6) → [((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid (131506-22-4)

Guidance literature:

With potassium hydroxide; In ethanol; for 16h; Ambient temperature;

DOI:10.1021/jm00082a005

Reference yield:

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) → [((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid (131506-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CDI / CH₂Cl₂ / 16 h / Ambient temperature

2: 1 N aq. KOH / ethanol / 16 h / Ambient temperature

With potassium hydroxide; 1,1'-carbonyldiimidazole; In ethanol; dichloromethane;

DOI:10.1021/jm00082a005

Reference yield:

exo-N-bicyclo[2.2.1]hept-2-yl-glycine ethyl ester (84827-39-4) → [((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid (131506-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CDI / CH₂Cl₂ / 16 h / Ambient temperature

2: 1 N aq. KOH / ethanol / 16 h / Ambient temperature

With potassium hydroxide; 1,1'-carbonyldiimidazole; In ethanol; dichloromethane;

DOI:10.1021/jm00082a005

upstream raw materials:

[((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-bicyclo[2.2.1]hept-2-yl-amino]-acetic acid ethyl ester

(S)-N-(benzyloxycarbonyl)valine

exo-N-bicyclo[2.2.1]hept-2-yl-glycine ethyl ester

Downstream raw materials:

N-((S)-1-{Bicyclo[2.2.1]hept-2-yl-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-4-(4-chloro-benzenesulfonylaminocarbonyl)-benzamide

N-((S)-1-{Bicyclo[2.2.1]hept-2-yl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-4-(4-chloro-benzenesulfonylaminocarbonyl)-benzamide

((S)-1-{Bicyclo[2.2.1]hept-2-yl-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester