(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid [1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

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Chemical Name:(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid [1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide
CAS No.:107994-10-5
Molecular Formula:C₂₆H₃₀N₄O₄S
Molecular Weight:494.615
Hs Code.:

Synonyms:(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid [1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

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Chemical Property of (S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid [1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

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Technology Process of (S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid [1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

There total 4 articles about (S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid [1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54731-09-8,118776-39-9
N-tosyl-L-prolyl chloride

: 107994-10-5
(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid [1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1 M NaOH / diethyl ether / 12 h

2: DCC / ethyl acetate; pyridine / 24 h / Ambient temperature

3: ethyl acetate; pyridine / 4 h / Ambient temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; In pyridine; diethyl ether; ethyl acetate;

Reference yield:

: 107994-07-0
Nα-(Tosyl-L-prolyl)-D,L-4-cyanphenylalanin

: 107994-10-5
(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid [1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / ethyl acetate; pyridine / 24 h / Ambient temperature

2: ethyl acetate; pyridine / 4 h / Ambient temperature

With dicyclohexyl-carbodiimide; In pyridine; ethyl acetate;

Reference yield:

: 51077-01-1,110771-95-4
L-N-tosyl-proline

: 107994-10-5
(S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid [1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 0.5 h / 60 °C

2: 1 M NaOH / diethyl ether / 12 h

3: DCC / ethyl acetate; pyridine / 24 h / Ambient temperature

4: ethyl acetate; pyridine / 4 h / Ambient temperature

With sodium hydroxide; thionyl chloride; dicyclohexyl-carbodiimide; In pyridine; diethyl ether; ethyl acetate;