2'-amino-6-(3-chloro-5-((trimethylsilyl)ethynyl)phenyl)-1',2,2-trimethylspiro[chroman-4,4'-imidazol]-5'(1'H)-one

Base Information

Chemical Name:2'-amino-6-(3-chloro-5-((trimethylsilyl)ethynyl)phenyl)-1',2,2-trimethylspiro[chroman-4,4'-imidazol]-5'(1'H)-one
CAS No.:1311265-12-9
Molecular Formula:C₂₅H₂₈ClN₃O₂Si
Molecular Weight:466.055
Hs Code.:

Synonyms:2'-amino-6-(3-chloro-5-((trimethylsilyl)ethynyl)phenyl)-1',2,2-trimethylspiro[chroman-4,4'-imidazol]-5'(1'H)-one

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Chemical Property of 2'-amino-6-(3-chloro-5-((trimethylsilyl)ethynyl)phenyl)-1',2,2-trimethylspiro[chroman-4,4'-imidazol]-5'(1'H)-one

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Technology Process of 2'-amino-6-(3-chloro-5-((trimethylsilyl)ethynyl)phenyl)-1',2,2-trimethylspiro[chroman-4,4'-imidazol]-5'(1'H)-one

There total 6 articles about 2'-amino-6-(3-chloro-5-((trimethylsilyl)ethynyl)phenyl)-1',2,2-trimethylspiro[chroman-4,4'-imidazol]-5'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1212010-85-9
2′-amino-6-bromo-1′,2,2-trimethylspiro[chroman-4,4′-imidazol]-5′(1′H)-one

: 942069-63-8
((3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethynyl)trimethylsilane

: 1311265-12-9
2'-amino-6-(3-chloro-5-((trimethylsilyl)ethynyl)phenyl)-1',2,2-trimethylspiro[chroman-4,4'-imidazol]-5'(1'H)-one

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 90 ℃; for 1h; Inert atmosphere; Sealed tube;

Reference yield:

: 82319-96-8
6-bromo-2,2-dimethylspiro[chroman-4,4′-imidazolidine]-2′,5′-dione

: 1311265-12-9
2'-amino-6-(3-chloro-5-((trimethylsilyl)ethynyl)phenyl)-1',2,2-trimethylspiro[chroman-4,4'-imidazol]-5'(1'H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

2: Lawessons reagent / toluene / 12 h / Reflux

3: tert.-butylhydroperoxide; ammonium hydroxide / methanol / 4 h / 40 °C

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere; Sealed tube

With Lawessons reagent; tert.-butylhydroperoxide; ammonium hydroxide; sodium hydride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1450-75-5
5-Bromo-2-hydroxyacetophenone

: 1311265-12-9
2'-amino-6-(3-chloro-5-((trimethylsilyl)ethynyl)phenyl)-1',2,2-trimethylspiro[chroman-4,4'-imidazol]-5'(1'H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyrrolidine / toluene / 18 h / Reflux

2.1: 72 h / 70 - 110 °C / Inert atmosphere; Sealed tube

2.2: 1 h / pH 5 / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

4.1: Lawessons reagent / toluene / 12 h / Reflux

5.1: tert.-butylhydroperoxide; ammonium hydroxide / methanol / 4 h / 40 °C

6.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere; Sealed tube

With pyrrolidine; Lawessons reagent; tert.-butylhydroperoxide; ammonium hydroxide; sodium hydride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene; mineral oil;