1-[((2-methoxyethoxy)methoxy)phenyl]-5-[2-(methoxymethoxy)phenyl]-pentan-3-ol

Base Information

Chemical Name:1-[((2-methoxyethoxy)methoxy)phenyl]-5-[2-(methoxymethoxy)phenyl]-pentan-3-ol
CAS No.:900509-56-0
Molecular Formula:C₂₃H₃₂O₆
Molecular Weight:404.503
Hs Code.:

Synonyms:1-[((2-methoxyethoxy)methoxy)phenyl]-5-[2-(methoxymethoxy)phenyl]-pentan-3-ol

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Chemical Property of 1-[((2-methoxyethoxy)methoxy)phenyl]-5-[2-(methoxymethoxy)phenyl]-pentan-3-ol

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Technology Process of 1-[((2-methoxyethoxy)methoxy)phenyl]-5-[2-(methoxymethoxy)phenyl]-pentan-3-ol

There total 10 articles about 1-[((2-methoxyethoxy)methoxy)phenyl]-5-[2-(methoxymethoxy)phenyl]-pentan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 900509-55-9
1-[((2-methoxyethoxy)methoxy)phenyl]-5-[2-(methoxymethoxy)phenyl]-pent-1-yn-3-ol

: 900509-56-0
1-[((2-methoxyethoxy)methoxy)phenyl]-5-[2-(methoxymethoxy)phenyl]-pentan-3-ol

Guidance literature:: With hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2006.04.026

Reference yield:

: 900509-51-5
3-(2-(methoxymethoxy)phenyl)propan-1-ol

: 900509-56-0
1-[((2-methoxyethoxy)methoxy)phenyl]-5-[2-(methoxymethoxy)phenyl]-pentan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 51 percent / 4 Angstroem molecular sieves; tetra-n-propylammonium perruthenate; 4-methylmorpholine N-oxide / CH₂Cl₂ / 1 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

2.2: 57 percent / tetrahydrofuran; hexane / -78 - 20 °C

3.1: 71 percent / H₂; K₂CO₃ / Pd/C / ethyl acetate / 2 h / 20 °C

With n-butyllithium; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; potassium carbonate; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2006.04.026

Reference yield:

: 900509-52-6
1-iodo-2-((2-methoxyethoxy)methoxy)benzene

: 900509-56-0
1-[((2-methoxyethoxy)methoxy)phenyl]-5-[2-(methoxymethoxy)phenyl]-pentan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / Ph₃P; Et₃N; CuI / PdCl₂(PPh₃)2 / 80 °C

2.1: 86 percent / NaOH / toluene / 3.5 h / Heating

3.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

3.2: 57 percent / tetrahydrofuran; hexane / -78 - 20 °C

4.1: 71 percent / H₂; K₂CO₃ / Pd/C / ethyl acetate / 2 h / 20 °C

With sodium hydroxide; copper(l) iodide; n-butyllithium; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; hexane; ethyl acetate; toluene; 1.1: Sonogashira coupling;
DOI:10.1016/j.tet.2006.04.026