(E)-3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-enoic acid ethyl ester
CAS No.:1028298-70-5
Molecular Formula:C₂₃H₂₁ClO₃
Molecular Weight:380.871
Hs Code.:

Synonyms:(E)-3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-enoic acid ethyl ester

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Chemical Property of (E)-3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-enoic acid ethyl ester

Chemical Property:

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Technology Process of (E)-3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-enoic acid ethyl ester

There total 1 articles about (E)-3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 1-[3-(5-chloro-naphthalen-2-ylmethoxy)-phenyl]-ethanone

: 1028298-70-5
(E)-3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-enoic acid ethyl ester

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In toluene; for 1h;

1-[3-(5-chloro-naphthalen-2-ylmethoxy)-phenyl]-ethanone; In tetrahydrofuran; toluene; for 48h; Further stages.;
DOI:10.1021/jm990476x

Reference yield:

: 1028298-70-5
(E)-3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-enoic acid ethyl ester

: 1026809-44-8
(E)-3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In diethyl ether; at -78 ℃; for 0.5h;
DOI:10.1021/jm990476x

Reference yield:

: 1028298-70-5
(E)-3-[3-(5-Chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-enoic acid ethyl ester

: 1025932-03-9
N-{3-[3-(5-chloro-naphthalen-2-ylmethoxy)-phenyl]-but-2-enyl}-hydroxylamine

Guidance literature:: Multi-step reaction with 3 steps

1: DIBAL / diethyl ether / 0.5 h / -78 °C

2: diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 1 h / 0 °C

3: TFA / CH₂Cl₂ / 8 h

With diisobutylaluminium hydride; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Reduction / 2: Condensation / 3: acidolysis;
DOI:10.1021/jm990476x