(1R,7R,8R,11S)-11-Benzylamino-7-hydroxy-9-thia-2-aza-bicyclo[6.2.1]undecan-3-one

Base Information

Chemical Name:(1R,7R,8R,11S)-11-Benzylamino-7-hydroxy-9-thia-2-aza-bicyclo[6.2.1]undecan-3-one
CAS No.:85416-25-7
Molecular Formula:C₁₆H₂₂N₂O₂S
Molecular Weight:306.429
Hs Code.:

Synonyms:(1R,7R,8R,11S)-11-Benzylamino-7-hydroxy-9-thia-2-aza-bicyclo[6.2.1]undecan-3-one

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Chemical Property of (1R,7R,8R,11S)-11-Benzylamino-7-hydroxy-9-thia-2-aza-bicyclo[6.2.1]undecan-3-one

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Technology Process of (1R,7R,8R,11S)-11-Benzylamino-7-hydroxy-9-thia-2-aza-bicyclo[6.2.1]undecan-3-one

There total 9 articles about (1R,7R,8R,11S)-11-Benzylamino-7-hydroxy-9-thia-2-aza-bicyclo[6.2.1]undecan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55183-45-4
hex-5-in-carboxyl chloride

: 85416-25-7
(1R,7R,8R,11S)-11-Benzylamino-7-hydroxy-9-thia-2-aza-bicyclo[6.2.1]undecan-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / pyridine; CH₂Cl₂ / 0 °C

2: 65 percent / Zn / acetic acid

3: 95 percent / diisobutylaluminum hydride / toluene / -78 °C

4: 72 percent / CH₂Cl₂

5: 63 percent / BaO / toluene / Heating; further reagent

6: Zn, AcOH / H₂O / 70 °C

With diisobutylaluminium hydride; acetic acid; barium(II) oxide; zinc; In pyridine; dichloromethane; water; acetic acid; toluene;
DOI:10.1021/ja00387a057

Reference yield:

: 83486-94-6
(R)-2-Hex-5-ynoylamino-3-((R)-2-hex-5-ynoylamino-2-methoxycarbonyl-ethyldisulfanyl)-propionic acid methyl ester

: 85416-25-7
(1R,7R,8R,11S)-11-Benzylamino-7-hydroxy-9-thia-2-aza-bicyclo[6.2.1]undecan-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / Zn / acetic acid

2: 95 percent / diisobutylaluminum hydride / toluene / -78 °C

3: 72 percent / CH₂Cl₂

4: 63 percent / BaO / toluene / Heating; further reagent

5: Zn, AcOH / H₂O / 70 °C

With diisobutylaluminium hydride; acetic acid; barium(II) oxide; zinc; In dichloromethane; water; acetic acid; toluene;
DOI:10.1021/ja00387a057

Reference yield:

: 29601-98-7
N-benzylhydroxylamine hydrochloride

: 85416-25-7
(1R,7R,8R,11S)-11-Benzylamino-7-hydroxy-9-thia-2-aza-bicyclo[6.2.1]undecan-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / CH₂Cl₂

2: 63 percent / BaO / toluene / Heating; further reagent

3: Zn, AcOH / H₂O / 70 °C

With acetic acid; barium(II) oxide; zinc; In dichloromethane; water; toluene;
DOI:10.1021/ja00387a057