(S)-3-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-butanoic acid tert-butyl ester

Base Information

Chemical Name:(S)-3-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-butanoic acid tert-butyl ester
CAS No.:688020-55-5
Molecular Formula:C₂₆H₂₈ClF₃N₂O₅
Molecular Weight:540.967
Hs Code.:

Synonyms:(S)-3-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-butanoic acid tert-butyl ester

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Chemical Property of (S)-3-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-butanoic acid tert-butyl ester

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Technology Process of (S)-3-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-butanoic acid tert-butyl ester

There total 1 articles about (S)-3-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-butanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 688020-55-5
(S)-3-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-butanoic acid tert-butyl ester

Guidance literature:: (R)-3-[3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-propionyl]-4-benzyl-oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

bromoacetic acid tert-butyl ester; at -78 - 20 ℃; for 24h;

Reference yield:

: 688020-55-5
(S)-3-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-butanoic acid tert-butyl ester

: 688020-56-6
(S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-succinic acid-4-tert-butyl ester

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: (S)-3-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-butanoic acid tert-butyl ester; With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 2h;

With citric acid; sodium sulfite; In tetrahydrofuran; water; Acidic conditions;