Technology Process of 5-chloro-N-(3-(2,5-dichlorophenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
There total 10 articles about 5-chloro-N-(3-(2,5-dichlorophenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 3h;
Cooling with ice;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-iodo-succinimide / N,N-dimethyl-formamide / Heating; Inert atmosphere
2.1: triethylamine / palladium diacetate / 5 h / 55 °C / Inert atmosphere
3.1: water; lithium hydroxide / 3 h / 20 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / Reflux; Inert atmosphere
5.1: triethylamine / dichloromethane / 3 h / 20 °C / Cooling with ice; Inert atmosphere
With
N-iodo-succinimide; water; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate;
palladium diacetate;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / palladium diacetate / 5 h / 55 °C / Inert atmosphere
2.1: water; lithium hydroxide / 3 h / 20 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / Reflux; Inert atmosphere
4.1: triethylamine / dichloromethane / 3 h / 20 °C / Cooling with ice; Inert atmosphere
With
water; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate;
palladium diacetate;
In
dichloromethane;