1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate
CAS No.:1026786-65-1
Molecular Formula:C₂₈H₃₅Cl₂NO₆
Molecular Weight:552.495
Hs Code.:

Synonyms:1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate

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Chemical Property of 1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate

Chemical Property:

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Technology Process of 1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate

There total 11 articles about 1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4644-61-5
ethyl 4-piperidone-3-carboxylate hydrochloride

: 1026786-65-1
1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate

: 1-tert-butyl 3-ethyl (3S,4R)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / tert-butyl methyl ether; water / 18 h / 0 - 20 °C

2: sodium hydride / tetrahydrofuran / 20 h / 0 - 20 °C

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / propan-1-ol; water / 5 h / 80 °C

4: magnesium / methanol / 4.5 h / 20 °C / Heating / reflux

With sodium hydroxide; sodium hydride; sodium carbonate; magnesium; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; propan-1-ol; tert-butyl methyl ether; water;

Reference yield:

: 98977-34-5
1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate

: 1026786-65-1
1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate

: 1-tert-butyl 3-ethyl (3S,4R)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 20 h / 0 - 20 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / propan-1-ol; water / 5 h / 80 °C

3: magnesium / methanol / 4.5 h / 20 °C / Heating / reflux

With sodium hydride; sodium carbonate; magnesium; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; propan-1-ol; water;

Reference yield:

: 55162-34-0
1-bromo-4-(2-chloroethoxy)benzene

: 1026786-65-1
1-tert-butyl 3-ethyl (3R,4S)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate

: 1-tert-butyl 3-ethyl (3S,4R)-4-{4-(2-(2,6-dichloro-4-methyl-phenoxy)ethoxy)phenyl}-piperidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

1.2: 40 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - -70 °C

2.2: 1 h / -70 - 20 °C

2.3: 0.25 h

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / propan-1-ol; water / 5 h / 80 °C

4.1: magnesium / methanol / 4.5 h / 20 °C / Heating / reflux

With n-butyllithium; sodium carbonate; potassium carbonate; magnesium; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; propan-1-ol; water; N,N-dimethyl-formamide;