1-ref,2-cis-Bis-(p-tosyloxymethyl)-3-trans,4-trans-diphenyl-cyclobutan

Base Information

• Chemical Name: 1-ref,2-cis-Bis-(p-tosyloxymethyl)-3-trans,4-trans-diphenyl-cyclobutan
• CAS No.: 103397-59-7
• Molecular Formula: C₃₂H₃₂O₆S₂
• Molecular Weight: 576.734
• Mol file: 103397-59-7.mol

Synonyms:1-ref,2-cis-Bis-(p-tosyloxymethyl)-3-trans,4-trans-diphenyl-cyclobutan

Chemical Property of 1-ref,2-cis-Bis-(p-tosyloxymethyl)-3-trans,4-trans-diphenyl-cyclobutan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ref,2-cis-Bis-(p-tosyloxymethyl)-3-trans,4-trans-diphenyl-cyclobutan

There total 4 articles about 1-ref,2-cis-Bis-(p-tosyloxymethyl)-3-trans,4-trans-diphenyl-cyclobutan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-Bis(hydroxymethyl)-3,4-diphenylcyclobutane (19043-30-2) + p-toluenesulfonyl chloride (98-59-9) → 1-ref,2-cis-Bis-(p-tosyloxymethyl)-3-trans,4-trans-diphenyl-cyclobutan (103397-59-7)

Guidance literature:

With pyridine;

DOI:10.1021/ja01499a036

Reference yield:

β-truxinic acid (528-34-7,898816-27-8) → 1-ref,2-cis-Bis-(p-tosyloxymethyl)-3-trans,4-trans-diphenyl-cyclobutan (103397-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / BH₃*THF / tetrahydrofuran / 2 h / Heating

2: pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; borane-THF; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00102a012

Reference yield:

→ 1-ref,2-cis-Bis-(p-tosyloxymethyl)-3-trans,4-trans-diphenyl-cyclobutan (103397-59-7)

Guidance literature:

Aus 1-ref,2-cis-Bis-(hydroxymethyl)-3-trans,4-trans-diphenyl-cyclobutan;

DOI:10.1016/0040-4020(68)88120-7

upstream raw materials:

1,2-Bis(hydroxymethyl)-3,4-diphenylcyclobutane

p-toluenesulfonyl chloride

β-truxinic acid