N-tert-butoxycarbonyl α,α-dimethylglycyl α,α-dimethylglycyl α,α-dimethylglycine

Base Information

Chemical Name:N-tert-butoxycarbonyl α,α-dimethylglycyl α,α-dimethylglycyl α,α-dimethylglycine
CAS No.:663604-50-0
Molecular Formula:C₁₇H₃₁N₃O₆
Molecular Weight:373.45
Hs Code.:

Synonyms:N-tert-butoxycarbonyl α,α-dimethylglycyl α,α-dimethylglycyl α,α-dimethylglycine

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Chemical Property of N-tert-butoxycarbonyl α,α-dimethylglycyl α,α-dimethylglycyl α,α-dimethylglycine

Chemical Property:

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Technology Process of N-tert-butoxycarbonyl α,α-dimethylglycyl α,α-dimethylglycyl α,α-dimethylglycine

There total 1 articles about N-tert-butoxycarbonyl α,α-dimethylglycyl α,α-dimethylglycyl α,α-dimethylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30992-29-1
Boc-Aib-OH

: 94744-50-0
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid

: 663604-50-0
N-tert-butoxycarbonyl α,α-dimethylglycyl α,α-dimethylglycyl α,α-dimethylglycine

Guidance literature:: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; solid phase reaction;

With piperidine; In dichloromethane; N,N-dimethyl-formamide; for 0.5h; solid phase reaction;

Boc-Aib-OH; Further stages;
DOI:10.1039/c2cc16665h

Reference yield:

: 80182-99-6
β-hydroxyphenylalanine methyl ester hydrochloride

: 663604-50-0
N-tert-butoxycarbonyl α,α-dimethylglycyl α,α-dimethylglycyl α,α-dimethylglycine

: Boc-(Aib)3-DL-Phe(β-OH)-OMe

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1021/ja039369p

Reference yield:

: 663604-50-0
N-tert-butoxycarbonyl α,α-dimethylglycyl α,α-dimethylglycyl α,α-dimethylglycine

: 663604-46-4
Boc-(Aib)3-ΔPhe-azlactone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.2 g / HOBt; DCC; Et₃N / CH₂Cl₂ / 20 °C

2: 1.7 g / aq. NaOH / methanol / 20 °C

3: 1.4 g / NaOAc / acetic anhydride / 20 °C

With sodium hydroxide; sodium acetate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; acetic anhydride;
DOI:10.1002/anie.200460703