(2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoic acid ammonium salt

Base Information

Chemical Name:(2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoic acid ammonium salt
CAS No.:1345982-42-4
Molecular Formula:C₂₅H₃₁NO₅S*H₃N
Molecular Weight:474.621
Hs Code.:

Synonyms:(2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoic acid ammonium salt

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Chemical Property of (2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoic acid ammonium salt

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Technology Process of (2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoic acid ammonium salt

There total 4 articles about (2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoic acid ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1345983-55-2
ethyl (2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoate

: 1345982-42-4
(2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoic acid ammonium salt

Guidance literature:: ethyl (2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride; In water; pH=1;

With ammonia; In water; acetonitrile;

Reference yield:

: (3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7,8-dimethoxy-5-phenyl-1-4-benzothiazepine-1,1-dioxide

: 1345982-42-4
(2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoic acid ammonium salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; aluminum (III) chloride / 1,2-dichloro-ethane / 2.5 h / 20 °C

1.2: Cooling with ice

2.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C / sealed tube

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

4.2: pH 1

With pyridine; hydrogenchloride; aluminum (III) chloride; water; triethylamine; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: (3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-5-phenyl-1,4-benzothiazepine-8-ol 1,1-dioxide

: 1345982-42-4
(2E)-3-[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]-2-propenoic acid ammonium salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C / sealed tube

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3.2: pH 1

With pyridine; water; triethylamine; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;