(3-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (3-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 610302-03-9
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.293
• Hs Code.: 2924299090
• Mol file: 610302-03-9.mol

Synonyms:TERT-BUTYL 3-HYDROXYCYCLOHEXYL CARBAMATE;(3-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER;3-N-BOC-AMINO-CYCLOHEXANOL;Carbamic acid, (3-hydroxycyclohexyl)-, 1,1-dimethylethyl ester (9CI);5-amino-2-methylpyridine-3-carboxylic acid;1-N-Boc aminocyclohexan-3-ol;cis-1-N-Boc-3-hydroxy-cyclohexylamine(racemic);trans-1-N-Boc-3-hydroxy-cyclohexylamine (racemic)

Chemical Property of (3-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 7.02E-06mmHg at 25°C
• Refractive Index: 1.485
• Boiling Point: 337.7 °C at 760 mmHg
• PKA: 12.32±0.40(Predicted)
• Flash Point: 158 °C
• PSA: 58.56000
• Density: 1.06 g/cm³
• LogP: 2.20550
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(3-Hydroxy-cyclohexyl)-carbamicacidtert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER

There total 3 articles about (3-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3-oxo-cyclohexyl)-carbamic acid tert-butyl ester (885280-38-6,1803033-61-5,1383797-87-2) → tert-butyl N-(3-hydroxycyclohexyl)carbamate (610302-03-9,1425253-99-1,1638744-95-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 14h;

Reference yield: 78.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-aminocyclohexanol (6850-39-1) → tert-butyl N-(3-hydroxycyclohexyl)carbamate (610302-03-9,1425253-99-1,1638744-95-2)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 16h;

Reference yield:

→ tert-butyl N-(3-hydroxycyclohexyl)carbamate (610302-03-9,1425253-99-1,1638744-95-2)

Guidance literature:

upstream raw materials:

di-tert-butyl dicarbonate

3-aminocyclohexanol

(3-oxo-cyclohexyl)-carbamic acid tert-butyl ester

Downstream raw materials:

tert-butyl 3-(2-fluorophenoxy)cyclohexylcarbamate

C₁₁H₂₁NO₃

(+/-)-cis-3-amino-cyclohexanol; hydrochloride