2-[4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decane-1,8-dione

Base Information

Chemical Name:2-[4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decane-1,8-dione
CAS No.:1292278-83-1
Molecular Formula:C₁₈H₂₀F₃NO₃
Molecular Weight:355.357
Hs Code.:

Synonyms:2-[4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decane-1,8-dione

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Chemical Property of 2-[4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decane-1,8-dione

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Technology Process of 2-[4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decane-1,8-dione

There total 10 articles about 2-[4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decane-1,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292779-83-9
8-hydroxy-2-[4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decan-1-one

: 1292278-83-1
2-[4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decane-1,8-dione

Guidance literature:: With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide; In dichloromethane; water; at 20 ℃; for 3.66667h;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1292278-83-1
2-[4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decane-1,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 °C

1.2: 13.5 h / 5 - 20 °C

1.3: 12 h / 20 °C

2.1: toluene / 0.17 h / 20 °C

2.2: 95 °C / Reflux

3.1: sodium hydrogencarbonate; sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 3.67 h / 20 °C

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydride; sodium hydrogencarbonate; potassium bromide; In dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 4-((R)-2,2,2-trifluoro-1-methylethoxy)nitrophenyl

: 1292278-83-1
2-[4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decane-1,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C

2.1: toluene / 0.17 h / 20 °C

2.2: 18.75 h / 95 °C / Reflux

3.1: sodium hydrogencarbonate; sodium hypochlorite; potassium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 3.5 h / 20 °C

With sodium hypochlorite; hydrogen; sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; In methanol; dichloromethane; water; toluene;