ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-5-carboxylate hydrochloride

Base Information

Chemical Name:ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-5-carboxylate hydrochloride
CAS No.:1290128-98-1
Molecular Formula:C₁₅H₁₉N₃O₃*ClH
Molecular Weight:325.795
Hs Code.:

Synonyms:ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-5-carboxylate hydrochloride

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Chemical Property of ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-5-carboxylate hydrochloride

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Technology Process of ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-5-carboxylate hydrochloride

There total 5 articles about ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-5-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290128-81-2
1-tert-butyl 5-ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-1,5-dicarboxylate

: 1290128-98-1
ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-5-carboxylate hydrochloride

Guidance literature:: 1-tert-butyl 5-ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-1,5-dicarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; toluene; Inert atmosphere;
DOI:10.1016/j.tet.2011.01.092

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1290128-98-1
ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-5-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride / water / 0.5 h / 100 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / methanol / 1 h / 0 - 45 °C / Inert atmosphere

4.1: pyridinium p-toluenesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.2: Inert atmosphere

With N-benzyl-N,N,N-triethylammonium chloride; pyridinium p-toluenesulfonate; sodium hydride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2011.01.092

Reference yield:

: 1290128-72-1
1-tert-butyl 5-ethyl 4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-1,5-dicarboxylate

: 1290128-98-1
ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-5-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 1 h / 0 - 45 °C / Inert atmosphere

2.1: pyridinium p-toluenesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With pyridinium p-toluenesulfonate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/j.tet.2011.01.092