1-(5-(1-(2,6-difluorobenzyl)-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)-1-(4-methylthiazol-2-yl)ethanol

Base Information

Chemical Name:1-(5-(1-(2,6-difluorobenzyl)-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)-1-(4-methylthiazol-2-yl)ethanol
CAS No.:1251929-26-6
Molecular Formula:C₁₈H₁₆F₂N₆OS₂
Molecular Weight:434.493
Hs Code.:

Synonyms:1-(5-(1-(2,6-difluorobenzyl)-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)-1-(4-methylthiazol-2-yl)ethanol

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Chemical Property of 1-(5-(1-(2,6-difluorobenzyl)-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)-1-(4-methylthiazol-2-yl)ethanol

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Technology Process of 1-(5-(1-(2,6-difluorobenzyl)-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)-1-(4-methylthiazol-2-yl)ethanol

There total 9 articles about 1-(5-(1-(2,6-difluorobenzyl)-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)-1-(4-methylthiazol-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1251930-25-2
C₁₈H₁₈F₂N₆O₂S₂

: 1251929-26-6
1-(5-(1-(2,6-difluorobenzyl)-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)-1-(4-methylthiazol-2-yl)ethanol

Guidance literature:: C₁₈H₁₈F₂N₆O₂S₂; With sulfuric acid; at 20 ℃; for 4h; Cooling with ice;

With ammonia; In water; Cooling with ice;

Reference yield:

: 1251929-90-4
2-hydroxy-2-(4-methyl-1,3-thiazol-2-yl)propanohydrazide

: 1473417-21-8
1-(2,6-difluorobenzyl)-3-isocyanato-1H-pyrazole

: 1251929-26-6
1-(5-(1-(2,6-difluorobenzyl)-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)-1-(4-methylthiazol-2-yl)ethanol

Guidance literature:: 2-hydroxy-2-(4-methyl-1,3-thiazol-2-yl)propanohydrazide; 1-(2,6-difluorobenzyl)-3-isocyanato-1H-pyrazole; In ethanol; for 2h; Reflux; Inert atmosphere;

With sulfuric acid; In ethanol; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm4012033

Reference yield:

: 1251929-88-0
ethyl 2-(4-methyl-1,3-thiazol-2-yl)propanoate

: 1251929-26-6
1-(5-(1-(2,6-difluorobenzyl)-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)-1-(4-methylthiazol-2-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 7 h / Reflux

2.1: ethanol / 1 h / Reflux

3.1: sulfuric acid / 4 h / 20 °C / Cooling with ice

3.2: Cooling with ice

With sulfuric acid; hydrazine hydrate; In ethanol;