(6E)-3,6-anhydro-1,2:4,5-bis-O-(1-methylethylidene)-7-deoxy-7-(3-nitrophenyl)-7-phenyl-L-gluco-hept-6-enitol

Base Information

Chemical Name:(6E)-3,6-anhydro-1,2:4,5-bis-O-(1-methylethylidene)-7-deoxy-7-(3-nitrophenyl)-7-phenyl-L-gluco-hept-6-enitol
CAS No.:1198465-42-7
Molecular Formula:C₂₅H₂₇NO₇
Molecular Weight:453.492
Hs Code.:

Synonyms:(6E)-3,6-anhydro-1,2:4,5-bis-O-(1-methylethylidene)-7-deoxy-7-(3-nitrophenyl)-7-phenyl-L-gluco-hept-6-enitol

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Chemical Property of (6E)-3,6-anhydro-1,2:4,5-bis-O-(1-methylethylidene)-7-deoxy-7-(3-nitrophenyl)-7-phenyl-L-gluco-hept-6-enitol

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Technology Process of (6E)-3,6-anhydro-1,2:4,5-bis-O-(1-methylethylidene)-7-deoxy-7-(3-nitrophenyl)-7-phenyl-L-gluco-hept-6-enitol

There total 3 articles about (6E)-3,6-anhydro-1,2:4,5-bis-O-(1-methylethylidene)-7-deoxy-7-(3-nitrophenyl)-7-phenyl-L-gluco-hept-6-enitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1198465-29-0
(6Z)-3,6-anhydro-1,2:4,5-bis-O-(1-methylethylidene)-7-bromo-7-deoxy-7-(3-nitrophenyl)-L-gluco-hept-6-enitol

: 98-80-6
phenylboronic acid

: 1198465-42-7
(6E)-3,6-anhydro-1,2:4,5-bis-O-(1-methylethylidene)-7-deoxy-7-(3-nitrophenyl)-7-phenyl-L-gluco-hept-6-enitol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; trifuran-2-yl-phosphane; potassium carbonate; In 1,2-dimethoxyethane; water; at 85 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tetlet.2009.09.019

Reference yield:

: 13331-27-6
m-nitrobenzene boronic acid

: 1198465-42-7
(6E)-3,6-anhydro-1,2:4,5-bis-O-(1-methylethylidene)-7-deoxy-7-(3-nitrophenyl)-7-phenyl-L-gluco-hept-6-enitol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.17 h

1.2: 24 h / 85 °C

2.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.17 h

2.2: 24 h / 85 °C

With potassium carbonate; In 1,2-dimethoxyethane; water; 1.2: Suzuki coupling / 2.2: Suzuki coupling;
DOI:10.1002/ejoc.201100949

Reference yield:

: (3aR,6S,6aR)-4-Dibromomethylene-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

: 1198465-42-7
(6E)-3,6-anhydro-1,2:4,5-bis-O-(1-methylethylidene)-7-deoxy-7-(3-nitrophenyl)-7-phenyl-L-gluco-hept-6-enitol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.17 h

1.2: 24 h / 85 °C

2.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.17 h

2.2: 24 h / 85 °C

With potassium carbonate; In 1,2-dimethoxyethane; water; 1.2: Suzuki coupling / 2.2: Suzuki coupling;
DOI:10.1002/ejoc.201100949