(R)-3-benzyloxycarbonyl-5-<(R)-4-(2-benzyloxycarbonyl-2-methylhydrazino)-2-tert-butoxycarbonyl-4-oxobutyl>-2,2-dimethyl-1,3-oxazolidine

Base Information

Chemical Name:(R)-3-benzyloxycarbonyl-5-<(R)-4-(2-benzyloxycarbonyl-2-methylhydrazino)-2-tert-butoxycarbonyl-4-oxobutyl>-2,2-dimethyl-1,3-oxazolidine
CAS No.:142683-69-0
Molecular Formula:C₃₂H₄₄N₄O₈
Molecular Weight:612.723
Hs Code.:

Synonyms:(R)-3-benzyloxycarbonyl-5-<(R)-4-(2-benzyloxycarbonyl-2-methylhydrazino)-2-tert-butoxycarbonyl-4-oxobutyl>-2,2-dimethyl-1,3-oxazolidine

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Chemical Property of (R)-3-benzyloxycarbonyl-5-<(R)-4-(2-benzyloxycarbonyl-2-methylhydrazino)-2-tert-butoxycarbonyl-4-oxobutyl>-2,2-dimethyl-1,3-oxazolidine

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Technology Process of (R)-3-benzyloxycarbonyl-5-<(R)-4-(2-benzyloxycarbonyl-2-methylhydrazino)-2-tert-butoxycarbonyl-4-oxobutyl>-2,2-dimethyl-1,3-oxazolidine

There total 6 articles about (R)-3-benzyloxycarbonyl-5-<(R)-4-(2-benzyloxycarbonyl-2-methylhydrazino)-2-tert-butoxycarbonyl-4-oxobutyl>-2,2-dimethyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135638-41-4
(R)-3-benzyloxycarbonyl-5-<(Z)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)vinyl>-2,2-dimethyl-1,3-oxazolidine

: 142683-69-0
(R)-3-benzyloxycarbonyl-5-<(R)-4-(2-benzyloxycarbonyl-2-methylhydrazino)-2-tert-butoxycarbonyl-4-oxobutyl>-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / H₂ / (S,S)-BF₄ / methanol / 12 h / 2250.2 Torr / Ambient temperature

2: 100 percent / 1 N aq. LiOH / dioxane; H₂O / 1 h / Ambient temperature

3: 1) isobutyl chloroformate, Et₃N / 1) THF, -10 deg C, 10 min, 2) Et₂O, 0 deg C, 14 h

4: silver benzoate, Et₃N / methanol / 0.17 h / 60 °C

5: 100 percent / 1 N aq. LiOH / dioxane; H₂O / 1 h / Ambient temperature

6: 1) Et₃N, ethyl chloroformate / 1) THF, -20 deg C, 10 min, 2) THF, to room temperature, 12 h

With lithium hydroxide; hydrogen; silver benzoate; chloroformic acid ethyl ester; triethylamine; isobutyl chloroformate; (S,S)-BF4; In 1,4-dioxane; methanol; water;
DOI:10.1055/s-1992-26142

Reference yield:

: 142683-63-4
(R)-3-benzyloxycarbonyl-5-<(S)-2-(tert-butoxycarbonylamino)-2-carboxyethyl>-2,2-dimethyl-1,3-oxazolidine

: 142683-69-0
(R)-3-benzyloxycarbonyl-5-<(R)-4-(2-benzyloxycarbonyl-2-methylhydrazino)-2-tert-butoxycarbonyl-4-oxobutyl>-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1) isobutyl chloroformate, Et₃N / 1) THF, -10 deg C, 10 min, 2) Et₂O, 0 deg C, 14 h

2: silver benzoate, Et₃N / methanol / 0.17 h / 60 °C

3: 100 percent / 1 N aq. LiOH / dioxane; H₂O / 1 h / Ambient temperature

4: 1) Et₃N, ethyl chloroformate / 1) THF, -20 deg C, 10 min, 2) THF, to room temperature, 12 h

With lithium hydroxide; silver benzoate; chloroformic acid ethyl ester; triethylamine; isobutyl chloroformate; In 1,4-dioxane; methanol; water;
DOI:10.1055/s-1992-26142

Reference yield:

: 142683-64-5
(R)-3-benzyloxycarbonyl-5-<(R)-2-(tert-butoxycarbonylamino)-3-(methoxycarbonyl)propyl>-2,2-dimethyl-1,3-oxazolidine

: 142683-69-0
(R)-3-benzyloxycarbonyl-5-<(R)-4-(2-benzyloxycarbonyl-2-methylhydrazino)-2-tert-butoxycarbonyl-4-oxobutyl>-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1 N aq. LiOH / dioxane; H₂O / 1 h / Ambient temperature

2: 1) Et₃N, ethyl chloroformate / 1) THF, -20 deg C, 10 min, 2) THF, to room temperature, 12 h

With lithium hydroxide; chloroformic acid ethyl ester; triethylamine; In 1,4-dioxane; water;
DOI:10.1055/s-1992-26142