DIBOC-IODO-L-DOPA

Base Information

• Chemical Name: DIBOC-IODO-L-DOPA
• CAS No.: 143993-89-9
• Molecular Formula: C₂₂H₃₀INO₉
• Molecular Weight: 579.386
• Mol file: 143993-89-9.mol

Synonyms:DiBoc-iodo-L-tyrosine;N-FORMYL-3,4-DI-TERT-BUTOXYCARBONYLOXY-6-IODO-L-PHENYLALANINE ETHYL ESTER;L-Tyrosine,5-[[(1,1-dimethylethoxy)carbonyl]oxy]-N-formyl-2-iodo-,ethyl ester,1,1-dimethylethyl carbonate;

Chemical Property of DIBOC-IODO-L-DOPA

Chemical Property:

• Boiling Point: 650.6 °C at 760 mmHg
• Flash Point: 347.3 °C
• PSA: 126.46000
• Density: 1.421 g/cm³
• LogP: 5.16600

Purity/Quality:

98.5% ^*data from raw suppliers

DIBOC-IODO-L-DOPA 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIBOC-IODO-L-DOPA

There total 2 articles about DIBOC-IODO-L-DOPA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-formyl-3,4-dihydroxy-6-iodo-L-phenylalanine ethyl ester + di-tert-butyl dicarbonate (24424-99-5) → N-formyl-3,4-di-t-butoxycarbonyloxy-6-iodo-L-phenylalanine ethyl ester (143993-89-9)

Guidance literature:

With triethylamine; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

N-formyl-3,4-dimethoxy-L-phenylalanine ethyl ester → N-formyl-3,4-di-t-butoxycarbonyloxy-6-iodo-L-phenylalanine ethyl ester (143993-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: iodine; silver trifluoroacetate / dichloromethane; ethyl acetate; Petroleum ether

2: dichloromethane; boron tribromide

3: triethylamine / ethyl acetate; N,N-dimethyl-formamide

With iodine; silver trifluoroacetate; triethylamine; In dichloromethane; boron tribromide; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether;

upstream raw materials:

di-tert-butyl dicarbonate