2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Base Information

Chemical Name:2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1346448-11-0
Molecular Formula:C₂₄H₂₂ClN₇O₃
Molecular Weight:491.937
Hs Code.:

Synonyms:2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Suppliers and Price of 2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

There total 9 articles about 2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1346448-10-9
2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

: 1346448-11-0
2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: 2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2.5h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1346448-11-0
2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 48 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide

2.2: 1 h / 0 - 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.5 h / 20 °C

4.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 14 h / 85 °C

5.1: ammonium chloride; iron / ethanol; water / 0.5 h / 90 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.03 h / 0 °C

7.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 20 °C

With N-chloro-succinimide; potassium tert-butylate; iron; sodium hydride; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 118-48-9
isatoic anhydride

: 1346448-11-0
2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1,4-dioxane / 0.33 h

2: potassium tert-butylate / N,N-dimethyl-formamide / 1.5 h / 20 °C

3: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 14 h / 85 °C

4: ammonium chloride; iron / ethanol; water / 0.5 h / 90 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.03 h / 0 °C

6: trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 20 °C

With potassium tert-butylate; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;