Chemical Property of AG 1478
Chemical Property:
- Boiling Point:458.465 °C at 760 mmHg
- Flash Point:231.072 °C
- PSA：56.27000
- Density:1.338 g/cm3
- LogP:4.11700
- Storage Temp.:2-8°C
- Solubility.:0.1 M HCl: soluble
- Purity/Quality:
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≥ 98% *data from raw suppliers
Tyrphostin AG 1478 ≥98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines.1,2 AG-1478 reduces pulmonary fibrosis in a rat model.3?Cell permeable.
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Uses
Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431. Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.
