4-(N-acetyl)amino-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one

Base Information

Chemical Name:4-(N-acetyl)amino-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one
CAS No.:41455-73-6
Molecular Formula:C₂₀H₁₈N₂O₄S
Molecular Weight:382.44
Hs Code.:

Synonyms:4-(N-acetyl)amino-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one

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Chemical Property of 4-(N-acetyl)amino-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one

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Technology Process of 4-(N-acetyl)amino-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one

There total 8 articles about 4-(N-acetyl)amino-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

: 849413-58-7
4-N-(acetyl)amino-5,5-diethoxy-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indole

: 41455-73-6
4-(N-acetyl)amino-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one

Guidance literature:: With hydrogenchloride; In water; acetone; at 20 ℃; for 3h;
DOI:10.3987/COM-04-S(P)8

Reference yield:

: 3744-82-9
3,4-dihydrobenzo[cd]indol-5(1H)-one

: 41455-73-6
4-(N-acetyl)amino-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one

Guidance literature:: Multi-step reaction with 7 steps

1: 90.7 percent / Bu₄NHSO₄; KOH / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 77 percent / Br₂*1,4-dioxane / CCl₄; CHCl₃; diethyl ether / 3 h / 5 - 10 °C

3: 88 percent / NaN₃ / dimethylformamide; H₂O; acetic acid / 0.5 h / 5 - 20 °C

4: 74.6 percent / BF₃*OEt₂ / ethanol; CHCl₃ / 24 h / 20 °C

5: 90 percent / LAH / tetrahydrofuran / 3 h / 20 °C

6: 91.4 percent / HCOOH; pyridine / CH₂Cl₂

7: 85.6 percent / HCl / acetone; H₂O / 3 h / 20 °C

With pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; formic acid; sodium azide; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; dioxane dibromide; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.3987/COM-04-S(P)8

Reference yield:

: 37945-46-3
1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one

: 41455-73-6
4-(N-acetyl)amino-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / Br₂*1,4-dioxane / CCl₄; CHCl₃; diethyl ether / 3 h / 5 - 10 °C

2: 88 percent / NaN₃ / dimethylformamide; H₂O; acetic acid / 0.5 h / 5 - 20 °C

3: 74.6 percent / BF₃*OEt₂ / ethanol; CHCl₃ / 24 h / 20 °C

4: 90 percent / LAH / tetrahydrofuran / 3 h / 20 °C

5: 91.4 percent / HCOOH; pyridine / CH₂Cl₂

6: 85.6 percent / HCl / acetone; H₂O / 3 h / 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; formic acid; sodium azide; boron trifluoride diethyl etherate; dioxane dibromide; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.3987/COM-04-S(P)8