(3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

Base Information

Chemical Name:(3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol
CAS No.:81072-32-4
Molecular Formula:C₃₂H₄₁NO₃
Molecular Weight:487.682
Hs Code.:

(3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

Synonyms:(3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

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Chemical Property of (3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

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Technology Process of (3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

There total 1 articles about (3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1628-89-3
2-methoxypyridine

: 73336-58-0
3β-benzyloxy-5β-androst-15-en-17-one

: 81072-32-4
(3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) Et₂O, -70 deg C, 2.) Et₂O;

Reference yield: 91.0%

: 108-24-7
acetic anhydride

: 81072-32-4
(3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

: Acetic acid (3S,5R,8R,9S,10S,13S,14S,17S)-3-benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: With dmap; In pyridine;

Reference yield:

: 81072-32-4
(3S,5R,8R,9S,10S,13S,14S,17S)-3-Benzyloxy-17-(6-methoxy-pyridin-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

: 81072-38-0
3β-(benzyloxy)-14β-hydroxy-17β-<1-benzyl-2-hydroxy-5-pyridyl>-5β-androstane

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / 4-dimethylaminopyridine / pyridine

2: 84 percent / CaCO₃ / acetone; H₂O / 48 h / Heating

3: 96 percent / H₂ / 10percent Pd/CaCO₃ / ethanol

4: 85 percent / methanesulfonyl chloride / pyridine

5: 1.) N-bromosuccinimide, 2.) alumina / 1.) H₂O, acetone, RT, 30 min, 2.) acetone, CH₂Cl₂

6: 74 percent / LiAlH₄ / tetrahydrofuran / Heating

7: 52 percent / potassium carbonate / acetone / 24 h / Heating

With dmap; aluminum oxide; N-Bromosuccinimide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; methanesulfonyl chloride; calcium carbonate; Lindlar's catalyst; In tetrahydrofuran; pyridine; ethanol; water; acetone;