1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene

Base Information

• Chemical Name: 1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene
• CAS No.: 503000-47-3
• Molecular Formula: C₃₉H₅₇NO₄SeSi₂
• Molecular Weight: 739.017
• Mol file: 503000-47-3.mol

Synonyms:1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene

Chemical Property of 1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene

There total 6 articles about 1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ortho-nitrophenyl selenocyanate (51694-22-5) + 3-[3-(tert-butyldimethylsilyloxy)propyl]-3-[3-(tert-butyldiphenylsilyloxy)propyl]pent-4-en-1-ol (503000-31-5) → 1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene (503000-47-3)

Guidance literature:

With tributylphosphine; In tetrahydrofuran; at 20 ℃; for 14h;

DOI:10.1021/ol034020s

Reference yield:

4-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylbutanamide (215251-69-7) → 1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene (503000-47-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 63 percent / t-BuLi / tetrahydrofuran; pentane / -78 - 20 °C

2: 96 percent / NaH / 1,2-dimethoxy-ethane; various solvent(s) / 6 h / Heating

3: 99 percent / DIBAL-H / tetrahydrofuran; hexane / 0.5 h / 0 °C

4: 81 percent / Hg(OAc)2 / 24 h / Heating

5: 81 percent / triisobutylaluminum / CH₂Cl₂; hexane / 1 h / 20 °C

6: 14.35 g / n-Bu₃P / tetrahydrofuran / 14 h / 20 °C

With tributylphosphine; mercury(II) diacetate; tert.-butyl lithium; triisobutylaluminum; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; pentane; 2: Horner-Emmons reaction;

DOI:10.1021/ol034020s

Reference yield:

1-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-heptan-4-one (503000-45-1) → 1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene (503000-47-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / NaH / 1,2-dimethoxy-ethane; various solvent(s) / 6 h / Heating

2: 99 percent / DIBAL-H / tetrahydrofuran; hexane / 0.5 h / 0 °C

3: 81 percent / Hg(OAc)2 / 24 h / Heating

4: 81 percent / triisobutylaluminum / CH₂Cl₂; hexane / 1 h / 20 °C

5: 14.35 g / n-Bu₃P / tetrahydrofuran / 14 h / 20 °C

With tributylphosphine; mercury(II) diacetate; triisobutylaluminum; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; 1: Horner-Emmons reaction;

DOI:10.1021/ol034020s

upstream raw materials:

ortho-nitrophenyl selenocyanate

3-[3-(tert-butyldimethylsilyloxy)propyl]-3-[3-(tert-butyldiphenylsilyloxy)propyl]pent-4-en-1-ol

4-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylbutanamide

1-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-heptan-4-one

Downstream raw materials:

9-tert-butyldiphenylsiloxy-6,6-divinylnona-2-en-1-ol

7-tert-butyldiphenylsilyloxy-4,4-divinyl-1-heptanol

N-(6a-ethyl-decahydro-pyrrolo[3,2,1-ij]quinolin-9-ylidene)-N'-(2-methoxy-phenyl)-hydrazine

4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-vinyl-hex-5-enal