H-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OPac

Base Information

Chemical Name:H-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OPac
CAS No.:751450-50-7
Molecular Formula:C₅₄H₇₆N₆O₉
Molecular Weight:953.232
Hs Code.:

Synonyms:H-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OPac

Suppliers and Price of H-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OPac

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of H-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OPac

Chemical Property:

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Technology Process of H-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OPac

There total 11 articles about H-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OPac which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 139741-00-7
boc-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-Opac

: 751450-50-7
H-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OPac

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 2h; Ambient temperature;
DOI:10.1246/bcsj.65.228

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 751450-50-7
H-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OPac

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Et₃N, isobutyl chloroformate, 2.) Et₃N / 1.) THF, 2.) THF, chloroform, RT, 2 h

2: 98 percent / Zn / acetic acid / 2 h / Ambient temperature

3: 81 percent / 1-hydroxybenzotriazole, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimid hydrochloride / dimethylformamide / 0 °C

4: 84 percent / 2M HCl / dioxane / 2 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; zinc; isobutyl chloroformate; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.65.228

Reference yield:

: 38675-10-4
N-[(1,1-dimethylethoxy)carbonyl]-D-phenylalanyl-L-proline

: 751450-50-7
H-L-Val-L-Orn(Z)-L-Amy-D-Phe-L-Pro-OPac

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / Et₃N / ethyl acetate / 3 h / Ambient temperature

2: 100 percent / 2M HCl / dioxane / 2 h

3: 85 percent / 1-hydroxybenzotriazole, Et₃N, dicyclohexylcarbodiimide / CHCl₃ / a.) 0 deg C, 2 h, b.) RT, overnight

4: 98 percent / 2M HCl / dioxane / 2 h

5: 81 percent / 1-hydroxybenzotriazole, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimid hydrochloride / dimethylformamide / 0 °C

6: 84 percent / 2M HCl / dioxane / 2 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.65.228