BOC-L-4-BR-PHENYLALANINOL

Base Information

• Chemical Name: BOC-L-4-BR-PHENYLALANINOL
• CAS No.: 854760-84-2
• Molecular Formula: C14H20 Br N O3
• Molecular Weight: 330.222
• Hs Code.: 2924299090
• Mol file: 854760-84-2.mol

Synonyms:Carbamicacid, [(1S)-2-(4-bromophenyl)-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester(9CI); (2S)-2-(tert-Butoxycarbonylamino)-3-(4-bromophenyl)-1-propanol

Chemical Property of BOC-L-4-BR-PHENYLALANINOL

Chemical Property:

• PSA: 58.56000
• Density: 1.333
• LogP: 3.26810
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-tert-Butyl(1-amino-3-(4-bromophenyl)-1-oxopropan-2-yl)carbamate 99.94% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-L-4-BR-PHENYLALANINOL

There total 1 articles about BOC-L-4-BR-PHENYLALANINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine (62129-39-9,79561-82-3) → 1,1-dimethylethyl [(1S)-2-(4-bromophenyl)-1-(hydroxymethyl)ethyl]carbamate (854760-84-2)

Guidance literature:

4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine; With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 2h;

With sodium hydrogencarbonate; In diethyl ether; at 20 ℃; for 0.5h;

Reference yield: 65.0%

1,1-dimethylethyl [(1S)-2-(4-bromophenyl)-1-(hydroxymethyl)ethyl]carbamate (854760-84-2) + phthalimide (136918-14-4,85-41-6) → 1,1-dimethylethyl {(1S)-2-(4-bromophenyl)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}carbamate (869567-96-4)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Large scale reaction;

DOI:10.1021/op100186c

Reference yield:

1,1-dimethylethyl [(1S)-2-(4-bromophenyl)-1-(hydroxymethyl)ethyl]carbamate (854760-84-2) + tert-butyl 5-(5-hydroxypyridin-3-yl)-3-methyl-1H-indazole-1-carboxylate (944469-61-8) → C32H37BrN4O5

Guidance literature:

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jm0701019

upstream raw materials:

4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine

Downstream raw materials:

1,1-dimethylethyl {(1S)-2-(4-bromophenyl)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}carbamate

3-chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

C₂₆H₃₀N₂O₅

1,1-dimethylethyl {(1S)-2-[4-(bromoacetyl)phenyl]-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}carbamate

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