(5R)-N-(TERT-BUTOXYCARBONYL)-3,4,5,6-TETRAHYDRO-5-PHENYL-4(H)-1,4-OXAZIN-2-ONE

Base Information

Chemical Name:(5R)-N-(TERT-BUTOXYCARBONYL)-3,4,5,6-TETRAHYDRO-5-PHENYL-4(H)-1,4-OXAZIN-2-ONE
CAS No.:119878-90-9
Molecular Formula:C15H19 N O4
Molecular Weight:277.32
Hs Code.:2924297099
Mol file:119878-90-9.mol

Synonyms:(R)-TERT-BUTYL 2-OXO-5-PHENYLMORPHOLINE-4-CARBOXYLATE;(5R)-N-(TERT-BUTOXYCARBONYL)-3,4,5,6-TETRAHYDRO-5-PHENYL-4(H)-1,4-OXAZIN-2-ONE;(5R)-N-TERT BUTYLOXYCARBONYL -3,4,5,6-TETRAHYDRO-5-PHENYL-4(H)-1,4-OXAZIN-2-ONE

Suppliers and Price of (5R)-N-(TERT-BUTOXYCARBONYL)-3,4,5,6-TETRAHYDRO-5-PHENYL-4(H)-1,4-OXAZIN-2-ONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(5R)-N-(tert-Butoxycarbonyl)-3,4,5,6-tetrahydro-5-phenyl-4(H)-1,4-oxazin-2-one
100mg
$ 130.00

TRC
(5R)-N-(tert-Butoxycarbonyl)-3,4,5,6-tetrahydro-5-phenyl-4(H)-1,4-oxazin-2-one
50mg
$ 90.00

American Custom Chemicals Corporation
(R)-TERT-BUTYL 2-OXO-5-PHENYLMORPHOLINE-4-CARBOXYLATE 95.00%
5G
$ 2050.13

American Custom Chemicals Corporation
(R)-TERT-BUTYL 2-OXO-5-PHENYLMORPHOLINE-4-CARBOXYLATE 95.00%
250MG
$ 302.40

Total 14 raw suppliers

Chemical Property of (5R)-N-(TERT-BUTOXYCARBONYL)-3,4,5,6-TETRAHYDRO-5-PHENYL-4(H)-1,4-OXAZIN-2-ONE

Chemical Property:

Melting Point:87-89℃
Boiling Point:382.7 °C at 760 mmHg
Flash Point:185.2 °C
PSA：55.84000
Density:1.149 g/cm³
LogP:2.45950

Purity/Quality:

97% ^*data from raw suppliers

(5R)-N-(tert-Butoxycarbonyl)-3,4,5,6-tetrahydro-5-phenyl-4(H)-1,4-oxazin-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (5R)-N-(TERT-BUTOXYCARBONYL)-3,4,5,6-TETRAHYDRO-5-PHENYL-4(H)-1,4-OXAZIN-2-ONE

There total 2 articles about (5R)-N-(TERT-BUTOXYCARBONYL)-3,4,5,6-TETRAHYDRO-5-PHENYL-4(H)-1,4-OXAZIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 121269-45-2,134872-85-8
(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one

: 119878-90-9,220077-24-7
(5R)-4-(tert-butyloxycarbonyl)-5-phenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Guidance literature:: With triethylamine; In ethyl acetate; for 6h; Ambient temperature;
DOI:10.1021/jo00277a032

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 119878-90-9,220077-24-7
(5R)-4-(tert-butyloxycarbonyl)-5-phenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylethylamine / acetonitrile

2: ethyl acetate / 16 h / 25 °C

With N-ethyl-N,N-diisopropylamine; In ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4039(00)82269-8

Reference yield: 95.0%

: 119878-90-9,220077-24-7
(5R)-4-(tert-butyloxycarbonyl)-5-phenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 103935-55-3
4-chlorobutanol-1-trifluoromethanesulfonate

: (3R,5R)-2,3,5,6-tetrahydro-3-(4-chlorobutyl)-5-phenyl-N-(tert-butoxycarbonyl)-4H-1,4-oxazine-2-one

Guidance literature:: (5R)-4-(tert-butyloxycarbonyl)-5-phenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; at -78 ℃; for 0.5h;

4-chlorobutanol-1-trifluoromethanesulfonate; In tetrahydrofuran; 1,2-dimethoxyethane; for 2h;
DOI:10.1081/SCC-120021497