(E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide

Base Information

• Chemical Name: (E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide
• CAS No.: 1059174-79-6
• Molecular Formula: C₂₅H₂₅BrF₂N₄O₂
• Molecular Weight: 531.4

Synonyms:(E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide

Chemical Property of (E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide

Chemical Property:

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Technology Process of (E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide

There total 1 articles about (E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(E)-tert-butyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)-4-(2-(5-fluoro-1H-indol-3-yl)ethylcarbamoyl)piperidine-1-carboxylate (1059175-53-9) → (E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide (1059174-79-6)

Guidance literature:

(E)-tert-butyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)-4-(2-(5-fluoro-1H-indol-3-yl)ethylcarbamoyl)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydroxide; water; sodium hydrogencarbonate; In dichloromethane;

Reference yield: 83.0%

trimethylsilyl isocyanate (1118-02-1) + (E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide (1059174-79-6) → (E)-1-(3-(3-bromo-4-fluorophenyl)acrylamido)-N1-(2-(5-fluoro-1H-indol-3-yl)ethyl)cyclohexane-1,4-dicarboxamide (1059175-07-3)

Guidance literature:

In dichloromethane; isopropyl alcohol; at 20 ℃; for 18h;

Reference yield: 78.0%

(E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide (1059174-79-6) + ethyl isocyanate (109-90-0) → (E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N1-ethyl-N4-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-1,4-dicarboxamide (1059175-05-1)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

(E)-tert-butyl 4-(3-(3-bromo-4-fluorophenyl)acrylamido)-4-(2-(5-fluoro-1H-indol-3-yl)ethylcarbamoyl)piperidine-1-carboxylate

Downstream raw materials:

(E)-1-acetyl-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide

(E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-1-methylpiperidine-4-carboxamide

(E)-4-(3-(3-bromo-4-fluorophenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-1-(2,2,2-trifluoroacetyl)piperidine-4-carboxamide

(E)-1-(3-(3-bromo-4-fluorophenyl)acrylamido)-N₁-(2-(5-fluoro-1H-indol-3-yl)ethyl)cyclohexane-1,4-dicarboxamide

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