methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

Base Information

• Chemical Name: methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate
• CAS No.: 915771-72-1
• Molecular Formula: C₂₂H₂₅NO₇
• Molecular Weight: 415.443

Synonyms:methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

Chemical Property of methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

Chemical Property:

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Technology Process of methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

There total 1 articles about methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-methoxy-2-propanol (4984-22-9) → methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate (915771-72-1)

Guidance literature:

methyl 3-hydroxy-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 5 ℃; for 0.5h;

(R)-1-methoxy-2-propanol; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate (915771-72-1) → 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoic acid

Guidance literature:

methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 18h;

With hydrogenchloride; In water;

Reference yield:

methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate (915771-72-1) → 3-{[(1S)-2-hydroxy-1-methylethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-N-(5-methylpyrazin-2-yl)benzamide

Guidance literature:

Multi-step reaction with 5 steps

1: lithium hydroxide / tetrahydrofuran; water / 18 h / 20 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C

3: pyridine / dichloromethane / 0.08 h / 60 °C / Microwave

4: acetonitrile / 18 h / 20 °C

5: water; sodium hydrogencarbonate / acetonitrile

With pyridine; lithium hydroxide; oxalyl dichloride; water; sodium hydrogencarbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; acetonitrile;

upstream raw materials:

(R)-1-methoxy-2-propanol

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