1-(4-chloro-3-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Base Information

Chemical Name:1-(4-chloro-3-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
CAS No.:1442472-19-6
Molecular Formula:C₂₄H₂₁ClFN₅O₂
Molecular Weight:465.914
Hs Code.:

Synonyms:1-(4-chloro-3-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

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Chemical Property of 1-(4-chloro-3-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

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Technology Process of 1-(4-chloro-3-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

There total 15 articles about 1-(4-chloro-3-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1442470-89-4
3-(3-amino-6-chloro-2-fluorophenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one

: 103-71-9
phenyl isocyanate

: 1442472-19-6
1-(4-chloro-3-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 - 60 ℃;

Reference yield:

: 57946-56-2
2-fluoro-4-chloroaniline

: 1442472-19-6
1-(4-chloro-3-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 9 steps

1: acetic acid / 2 h / 20 °C

2: n-butyllithium / tetrahydrofuran / 4.75 h / -78 - 20 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5: dimethyl sulfoxide / 20 °C

6: hydrogenchloride / 7 h / 0 - 80 °C

7: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 1 h / Sonication

8: water; 1,4-dioxane / 100 °C

9: triethylamine / tetrahydrofuran / 20 - 60 °C

With hydrogenchloride; aluminum oxide; potassium fluoride; sodium tetrahydroborate; n-butyllithium; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide; water; acetic acid; dimethyl sulfoxide;

Reference yield:

: 1442470-80-5
N-(4-chloro-2-fluoro-3-(hydroxymethyl)phenyl)acetamide

: 1442472-19-6
1-(4-chloro-3-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: dimethyl sulfoxide / 20 °C

3: hydrogenchloride / 7 h / 0 - 80 °C

4: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 1 h / Sonication

5: water; 1,4-dioxane / 100 °C

6: triethylamine / tetrahydrofuran / 20 - 60 °C

With hydrogenchloride; aluminum oxide; potassium fluoride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide;