(2S,4aS)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ol

Base Information

Chemical Name:(2S,4aS)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ol
CAS No.:150255-24-6
Molecular Formula:C₂₇H₄₀O₅
Molecular Weight:444.612
Hs Code.:

Synonyms:(2S,4aS)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4aS)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,4aS)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ol

There total 11 articles about (2S,4aS)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150255-29-1
(S)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

: (2R,4aS)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ol

: 150255-24-6
(2S,4aS)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ol

Guidance literature:: With diisobutylaluminium hydride; In diethyl ether; Yield given. Yields of byproduct given; -78 deg C to room temperature;
DOI:10.1016/S0040-4039(00)93371-9

Reference yield:

: 4087-39-2
(S)-(+)-4,4a,5,6,7,8-hexahydro-4a-methyl-2(3H)-naphthalenone

: 150255-24-6
(2S,4aS)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH / benzene / Heating

2: 1) NaH / 1) PhCH₃, HMPA, 110 deg C, 12 h, 2) 0 deg C to room temperature

3: PhCO₂H, H₂O / 5 h / Ambient temperature

4: 97 percent / i-Pr₂NEt / CH₂Cl₂

5: LiAlH₄ / diethyl ether / -78 deg C to room temperature

With lithium aluminium tetrahydride; water; sodium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; benzoic acid; In diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(00)93371-9

Reference yield:

: 138331-71-2
N,N-Dimethyl-N'-[(S)-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-(2Z)-ylidene]-hydrazine

: 150255-24-6
(2S,4aS)-1-[(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methoxymethoxy-4-methyl-pent-4-enyl]-4a-methyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaH / 1) PhCH₃, HMPA, 110 deg C, 12 h, 2) 0 deg C to room temperature

2: PhCO₂H, H₂O / 5 h / Ambient temperature

3: 97 percent / i-Pr₂NEt / CH₂Cl₂

4: LiAlH₄ / diethyl ether / -78 deg C to room temperature

With lithium aluminium tetrahydride; water; sodium hydride; N-ethyl-N,N-diisopropylamine; benzoic acid; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)93371-9