2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE

Base Information

• Chemical Name: 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE
• CAS No.: 14396-89-5
• Molecular Formula: C12H9 N O2
• Molecular Weight: 199.209
• Hs Code.: 2925190090
• Mol file: 14396-89-5.mol

Synonyms:1H-Isoindole-1,3(2H)-dione,2-(1-methyl-2-propynyl)- (9CI); Phthalimide, N-(1-methyl-2-propynyl)- (8CI); 2-(1-Methylprop-2-ynyl)-1H-isoindole-1,3(2H)-dione;2-(1-Methylprop-2-ynyl)isoindole-1,3-dione; N-(1-Methyl-2-propynyl)phthalimide

Chemical Property of 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE

Chemical Property:

• Melting Point: 107-109℃
• Boiling Point: 310.1 °C at 760 mmHg
• Flash Point: 134.4 °C
• PSA: 37.38000
• Density: 1.285 g/cm³
• LogP: 1.24220

Purity/Quality:

98%min ^*data from raw suppliers

2-(But-3-Yn-2-Yl)Isoindoline-1,3-Dione ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE

There total 3 articles about 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

phthalimide (136918-14-4,85-41-6) + but-3-yn-2-ol (2028-63-9) → 2-(1-methylprop-2-ynyl)-1H-isoindole-1,3(2H)-dione (14396-89-5)

Guidance literature:

Mitsunobu conditions;

DOI:10.1002/ejoc.200400177

Reference yield:

1-methylprop-2-ynyl p-toluenesulfonate (53487-52-8) + potassium phtalimide (1074-82-4) → 2-(1-methylprop-2-ynyl)-1H-isoindole-1,3(2H)-dione (14396-89-5)

Guidance literature:

In N,N-dimethyl-formamide;

Reference yield:

→ 2-(1-methylprop-2-ynyl)-1H-isoindole-1,3(2H)-dione (14396-89-5)

Guidance literature:

3-Brom-1-butin, Kalium-phthalimid, in DMF, 70grad;

DOI:10.1021/jm00303a005

upstream raw materials:

phthalimide

but-3-yn-2-ol

1-methylprop-2-ynyl p-toluenesulfonate

potassium phtalimide

Downstream raw materials:

2-[1-methyl-3-(phenylseleno)prop-2-ynyl]-1H-isoindole-1,3(2H)dione

2-{3-[2-(4-isopropyl-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-isoindole-1,3-dione

2-{3-[2-(4-isopropoxyphenoxy)thiazol-5-yl]-1-methyl-prop-2-ynyl}isoindole-1,3-dione

2-{3-[4-(4-isopropoxy-phenoxy)-phenyl]-1-methyl-prop-2-ynyl}-isoindole-1,3-dione