2-(2-Formyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester

Base Information

• Chemical Name: 2-(2-Formyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester
• CAS No.: 188054-42-4
• Molecular Formula: C₁₆H₁₂F₃NO₃
• Molecular Weight: 323.271
• Mol file: 188054-42-4.mol

Synonyms:2-(2-Formyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester

Chemical Property of 2-(2-Formyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(2-Formyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester

There total 5 articles about 2-(2-Formyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(2-Hydroxymethyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester (190845-24-0) → 2-(2-Formyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester (188054-42-4)

Guidance literature:

With manganese(IV) oxide; In acetone; for 18h; Heating;

DOI:10.1021/jm970004n

Reference yield:

4-(trifluoromethyl)-2-{[2-(methoxycarbonyl)phenyl]amino}benzoic acid (188054-34-4) → 2-(2-Formyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester (188054-42-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 15 h / Ambient temperature

2: NaBH₄ / H₂O / 0.5 h

3: 85 percent / MnO₂ / acetone / 18 h / Heating

With manganese(IV) oxide; sodium tetrahydroborate; In tetrahydrofuran; water; acetone;

DOI:10.1021/jm970004n

Reference yield:

o-iodo-methyl-benzoic acid (610-97-9) → 2-(2-Formyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester (188054-42-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 43 percent / CuI, Cu powder, N-ethylmorpholine / various solvent(s) / 48 h / 100 °C

2: tetrahydrofuran / 15 h / Ambient temperature

3: NaBH₄ / H₂O / 0.5 h

4: 85 percent / MnO₂ / acetone / 18 h / Heating

With N-ethylmorpholine;; manganese(IV) oxide; sodium tetrahydroborate; copper(l) iodide; copper; In tetrahydrofuran; water; acetone;

DOI:10.1021/jm970004n

upstream raw materials:

2-(2-Hydroxymethyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester

o-iodo-methyl-benzoic acid

2-amino-4-trifluoromethylbenzoic acid

4-(trifluoromethyl)-2-{[2-(methoxycarbonyl)phenyl]amino}benzoic acid