1,2-bis{3-[2-(2-amino-3-methylphenyl)-4-hydroxycarbonylbenzimidazol-1-ylmethyl]phenoxy}ethane

Base Information

Chemical Name:1,2-bis{3-[2-(2-amino-3-methylphenyl)-4-hydroxycarbonylbenzimidazol-1-ylmethyl]phenoxy}ethane
CAS No.:651299-98-8
Molecular Formula:C₄₆H₄₀N₆O₆
Molecular Weight:772.86
Hs Code.:

Synonyms:1,2-bis{3-[2-(2-amino-3-methylphenyl)-4-hydroxycarbonylbenzimidazol-1-ylmethyl]phenoxy}ethane

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Chemical Property of 1,2-bis{3-[2-(2-amino-3-methylphenyl)-4-hydroxycarbonylbenzimidazol-1-ylmethyl]phenoxy}ethane

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Technology Process of 1,2-bis{3-[2-(2-amino-3-methylphenyl)-4-hydroxycarbonylbenzimidazol-1-ylmethyl]phenoxy}ethane

There total 7 articles about 1,2-bis{3-[2-(2-amino-3-methylphenyl)-4-hydroxycarbonylbenzimidazol-1-ylmethyl]phenoxy}ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 651300-23-1
1,2-bis{3-[4-ethoxycarbonyl-2-(3-methyl-2-aminophenyl)benzimidazol-1-ylmethyl]phenoxy}ethane

: 651299-98-8
1,2-bis{3-[2-(2-amino-3-methylphenyl)-4-hydroxycarbonylbenzimidazol-1-ylmethyl]phenoxy}ethane

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/ja030196d

Reference yield:

: 5437-38-7
3-methyl-2-nitrobenzoic acid

: 651299-98-8
1,2-bis{3-[2-(2-amino-3-methylphenyl)-4-hydroxycarbonylbenzimidazol-1-ylmethyl]phenoxy}ethane

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / 20 °C

2.1: Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

2.2: 91 percent / AcONa / acetic acid / 15 h / Heating

3.1: NaH / tetrahydrofuran / 0 - 20 °C

3.2: 87 percent / tetrahydrofuran / 22 h / 50 °C

4.1: 94 percent / SnCl₂; EtOH / 0.75 h / Heating

5.1: aq. LiOH / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide; oxalyl dichloride; ethanol; sodium hydride; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja030196d

Reference yield:

: 50424-93-6
3-methyl-2-nitrobenzoyl chloride

: 651299-98-8
1,2-bis{3-[2-(2-amino-3-methylphenyl)-4-hydroxycarbonylbenzimidazol-1-ylmethyl]phenoxy}ethane

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

1.2: 91 percent / AcONa / acetic acid / 15 h / Heating

2.1: NaH / tetrahydrofuran / 0 - 20 °C

2.2: 87 percent / tetrahydrofuran / 22 h / 50 °C

3.1: 94 percent / SnCl₂; EtOH / 0.75 h / Heating

4.1: aq. LiOH / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide; ethanol; sodium hydride; triethylamine; tin(ll) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja030196d