3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Base Information

Chemical Name:3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine
CAS No.:960299-67-6
Molecular Formula:C₂₄H₂₉FN₄O₃
Molecular Weight:440.518
Hs Code.:

Synonyms:3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

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Chemical Property of 3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

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Technology Process of 3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

There total 15 articles about 3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 960299-66-5
4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline

: 960299-67-6
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 17h; under 760.051 Torr;

Reference yield:

: 1061610-61-4
4-chloro-6-methoxy-7-(3-(4-methylpiperazin-1-yl)-propoxy)quinoline

: 960299-67-6
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: chlorobenzene / 30 h / 140 °C

2: iron; ammonium chloride / ethanol / 5 h / Reflux

With iron; ammonium chloride; In ethanol; chlorobenzene;
DOI:10.1002/ardp.201300029

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 960299-67-6
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / acetone / 20 - 25 °C

2: nitric acid / dichloromethane / 4 h / 0 °C

3: toluene / 10 h / 110 °C

4: iron; acetic acid / 2 h / 60 - 80 °C

5: acetonitrile / 10 h / 85 °C

6: trichlorophosphate / acetonitrile / 6 h / 85 °C

7: chlorobenzene / 30 h / 140 °C

8: iron; ammonium chloride / ethanol / 5 h / Reflux

With nitric acid; iron; potassium carbonate; ammonium chloride; acetic acid; trichlorophosphate; In ethanol; dichloromethane; chlorobenzene; acetone; toluene; acetonitrile;
DOI:10.1002/ardp.201300029