3-[pentafluorophenyl-(5-pentafluorobenzoyl-1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole

Base Information

Chemical Name:3-[pentafluorophenyl-(5-pentafluorobenzoyl-1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole
CAS No.:1402557-16-7
Molecular Formula:C₃₅H₃₀F₁₀N₂OSi
Molecular Weight:712.706
Hs Code.:

Synonyms:3-[pentafluorophenyl-(5-pentafluorobenzoyl-1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole

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Chemical Property of 3-[pentafluorophenyl-(5-pentafluorobenzoyl-1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole

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Technology Process of 3-[pentafluorophenyl-(5-pentafluorobenzoyl-1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole

There total 3 articles about 3-[pentafluorophenyl-(5-pentafluorobenzoyl-1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1402557-15-6
3-[pentafluorophenyl-(1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole

: 262267-31-2
S-pyridin-2-yl pentafluorobenzothioate

: 1402557-16-7
3-[pentafluorophenyl-(5-pentafluorobenzoyl-1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole

Guidance literature:: 3-[pentafluorophenyl-(1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole; With ethylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 0.35h; Inert atmosphere;

S-pyridin-2-yl pentafluorobenzothioate; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201203712

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 1402557-16-7
3-[pentafluorophenyl-(5-pentafluorobenzoyl-1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: magnesium / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / 2.17 h / 20 °C / Inert atmosphere

4.1: ethylmagnesium bromide / tetrahydrofuran / 0.35 h / 20 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

With ethylmagnesium bromide; sodium hydride; magnesium; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1002/anie.201203712

Reference yield:

: 181780-83-6
N-triisopropylsilylindole-3-carbaldehyde

: 1402557-16-7
3-[pentafluorophenyl-(5-pentafluorobenzoyl-1H-pyrrol-2-yl)methane]-1-triisopropylsilylindole

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / 2.17 h / 20 °C / Inert atmosphere

3.1: ethylmagnesium bromide / tetrahydrofuran / 0.35 h / 20 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With ethylmagnesium bromide; magnesium; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1002/anie.201203712