2-benzylamino-8-bromo-6-dimethylamino-9-phenethylpurine

Base Information

• Chemical Name: 2-benzylamino-8-bromo-6-dimethylamino-9-phenethylpurine
• CAS No.: 1609090-82-5
• Molecular Formula: C₂₂H₂₃BrN₆
• Molecular Weight: 451.369
• Mol file: 1609090-82-5.mol

Synonyms:2-benzylamino-8-bromo-6-dimethylamino-9-phenethylpurine

Chemical Property of 2-benzylamino-8-bromo-6-dimethylamino-9-phenethylpurine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-benzylamino-8-bromo-6-dimethylamino-9-phenethylpurine

There total 2 articles about 2-benzylamino-8-bromo-6-dimethylamino-9-phenethylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-benzylamino-6-dimethylamino-9-phenethylpurine (1609090-76-7) → 2-benzylamino-8-bromo-6-dimethylamino-9-phenethylpurine (1609090-82-5)

Guidance literature:

With pyridinium hydrobromide perbromide; In dichloromethane; at 20 ℃; regiospecific reaction; Inert atmosphere;

DOI:10.1371/journal.pone.0124423

Reference yield:

2-(N-tert-butoxycarbonyl)amino-6-chloro-9H-purine → 2-benzylamino-8-bromo-6-dimethylamino-9-phenethylpurine (1609090-82-5)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

2: tributylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 180 °C / Microwave irradiation; Inert atmosphere

4: pyridinium hydrobromide perbromide / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridinium hydrobromide perbromide; tributylphosphine; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2014.03.084

Reference yield: 73.0%

2-benzylamino-8-bromo-6-dimethylamino-9-phenethylpurine (1609090-82-5) + trimethylsilylacetylene (1066-54-2) → C24H24N6

Guidance literature:

2-benzylamino-8-bromo-6-dimethylamino-9-phenethylpurine; trimethylsilylacetylene; With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; at 110 ℃; Microwave irradiation;

In tetrahydrofuran;

DOI:10.1371/journal.pone.0124423

upstream raw materials:

2-benzylamino-6-dimethylamino-9-phenethylpurine