N-<(1R-(1α,2α,3α))-2-formyl-3-(2-propyl)cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Base Information

Chemical Name:N-<(1R-(1α,2α,3α))-2-formyl-3-(2-propyl)cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide
CAS No.:149859-25-6
Molecular Formula:C₂₇H₃₄N₂O₅
Molecular Weight:466.577
Hs Code.:

Synonyms:N-<(1R-(1α,2α,3α))-2-formyl-3-(2-propyl)cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Suppliers and Price of N-<(1R-(1α,2α,3α))-2-formyl-3-(2-propyl)cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-<(1R-(1α,2α,3α))-2-formyl-3-(2-propyl)cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-<(1R-(1α,2α,3α))-2-formyl-3-(2-propyl)cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

There total 8 articles about N-<(1R-(1α,2α,3α))-2-formyl-3-(2-propyl)cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 149859-35-8
N-<(1R-(1α,2α,3α))-2-(hydroxymethyl)-3-(2-propyl)-cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

: 149859-25-6
N-<(1R-(1α,2α,3α))-2-formyl-3-(2-propyl)cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90212-1

Reference yield:

: 82290-65-1
(Z)-4-methylpent-2-en-1-ol

: 149859-25-6
N-<(1R-(1α,2α,3α))-2-formyl-3-(2-propyl)cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / N,N-dimethylaniline, Et₃N / CH₂Cl₂ / 1) 0 deg C, 15 min, 2) r.t., 30 min

2: 85 percent / Rh₂<-CH₂-CH₂-CH(CO₂Me)-N=CO->4 / CH₂Cl₂ / Heating

3: 1) Me₃Al / 1) hexane, ClCH₂CH₂Cl, r.t., 1 h, 2) ClCH₂CH₂Cl, 83 deg C, 36 h

4: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

With trimethylaluminum; N,N-dimethyl-aniline; triethylamine; pyridinium chlorochromate; Rh2<-CH2-CH2-CH(CO2Me)-N=CO->4; In dichloromethane;
DOI:10.1016/S0040-4020(01)90212-1

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 149859-25-6
N-<(1R-(1α,2α,3α))-2-formyl-3-(2-propyl)cyclopropanoyl>-N'-(p-methoxybenzyl)-O-methyl-L-tyrosine-N-methylamide

Guidance literature:: Multi-step reaction with 6 steps

1: aq. NaOH

2: 1) i-BuOCOCl, NMM / 1) CH₂Cl₂, -60 deg C

3: HCl / dioxane; acetic acid

4: 81 percent / NaBH₄, 3 Angstroem molecular sieve / methanol

5: 1) Me₃Al / 1) hexane, ClCH₂CH₂Cl, r.t., 1 h, 2) ClCH₂CH₂Cl, 83 deg C, 36 h

6: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; 3 A molecular sieve; trimethylaluminum; pyridinium chlorochromate; isobutyl chloroformate; In 1,4-dioxane; methanol; dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(01)90212-1