Technology Process of (2S,3R)-N-Cbz-2,3-bisbenzyloxy-4-amino-butyric acid
There total 5 articles about (2S,3R)-N-Cbz-2,3-bisbenzyloxy-4-amino-butyric acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C26H23NO6;
With
methylamine;
In
tetrahydrofuran; water;
at 21 - 23 ℃;
for 22.5h;
benzyl chloroformate;
With
potassium carbonate;
In
tetrahydrofuran; water;
at 20 ℃;
for 25.5h;
With
hydrogenchloride;
In
water;
pH=~ 5;
- Guidance literature:
-
C18H21NO4; benzyl chloroformate;
With
potassium carbonate;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
With
hydrogenchloride;
In
water;
pH=5;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / isopropyl alcohol / 8 h / 80 - 82 °C
2.1: sodium hydride / tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / 18.5 h / -15 - 20 °C / Inert atmosphere
3.1: ozone / dichloromethane / -70 °C
4.1: 2-methyl-but-2-ene; sodium hypochlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol; tetrahydrofuran / 4 h / 10 - 20 °C
5.1: methylamine / water; tetrahydrofuran / 22.5 h / 5 - 23 °C
6.1: potassium carbonate / water; tetrahydrofuran / 25.5 h / 0 - 20 °C
6.2: pH ~ 5
With
pyridine; sodium hypochlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium hydride; potassium carbonate; ozone; methylamine;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; dichloromethane; water; isopropyl alcohol; mineral oil; tert-butyl alcohol;
4.1: Pinnick Oxidation;
