(S)-2-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-propionylamino]-3-(1H-indol-3-yl)-propionic acid phenyl ester; hydrochloride

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Chemical Name:(S)-2-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-propionylamino]-3-(1H-indol-3-yl)-propionic acid phenyl ester; hydrochloride
CAS No.:80647-73-0
Molecular Formula:C₂₄H₂₇N₅O₅*ClH
Molecular Weight:501.97
Hs Code.:

Synonyms:(S)-2-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-propionylamino]-3-(1H-indol-3-yl)-propionic acid phenyl ester; hydrochloride

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Chemical Property of (S)-2-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-propionylamino]-3-(1H-indol-3-yl)-propionic acid phenyl ester; hydrochloride

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Technology Process of (S)-2-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-propionylamino]-3-(1H-indol-3-yl)-propionic acid phenyl ester; hydrochloride

There total 4 articles about (S)-2-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-propionylamino]-3-(1H-indol-3-yl)-propionic acid phenyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 80647-63-8
Z-Asn-Ala-Trp-OPh

: 80647-73-0
(S)-2-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-propionylamino]-3-(1H-indol-3-yl)-propionic acid phenyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; for 3.5h;
DOI:10.1016/S0040-4020(01)98918-5

Reference yield:

: 74227-47-7
Z-Asn-Ala-OMe

: 80647-73-0
(S)-2-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-propionylamino]-3-(1H-indol-3-yl)-propionic acid phenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / hydrazine hydrate / dimethylformamide / 18 h / Ambient temperature

2: HCl, tert-butyl nitrite / dimethylformamide; dioxane / 0.17 h / -20 °C

3: TEA / dimethylformamide / 72 h / -10 °C

4: 96 percent / H₂, HCl / Pd/C / dimethylformamide / 3.5 h

With hydrogenchloride; tert.-butylnitrite; TEA; hydrogen; hydrazine hydrate; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)98918-5

Reference yield:

: [(S)-1-((S)-1-Azidocarbonyl-ethylcarbamoyl)-2-carbamoyl-ethyl]-carbamic acid benzyl ester

: 80647-73-0
(S)-2-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-propionylamino]-3-(1H-indol-3-yl)-propionic acid phenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: TEA / dimethylformamide / 72 h / -10 °C

2: 96 percent / H₂, HCl / Pd/C / dimethylformamide / 3.5 h

With hydrogenchloride; TEA; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)98918-5