(S)-8-Bromomethyl-6-[(E)-3-(3-tert-butoxycarbonylmethoxy-4-methoxy-phenyl)-acryloyl]-4-hydroxy-2-methyl-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester

Base Information

Chemical Name:(S)-8-Bromomethyl-6-[(E)-3-(3-tert-butoxycarbonylmethoxy-4-methoxy-phenyl)-acryloyl]-4-hydroxy-2-methyl-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester
CAS No.:1026035-80-2
Molecular Formula:C₃₀H₃₃BrN₂O₈
Molecular Weight:629.505
Hs Code.:

(S)-8-Bromomethyl-6-[(E)-3-(3-tert-butoxycarbonylmethoxy-4-methoxy-phenyl)-acryloyl]-4-hydroxy-2-methyl-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester

Synonyms:(S)-8-Bromomethyl-6-[(E)-3-(3-tert-butoxycarbonylmethoxy-4-methoxy-phenyl)-acryloyl]-4-hydroxy-2-methyl-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester

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Chemical Property of (S)-8-Bromomethyl-6-[(E)-3-(3-tert-butoxycarbonylmethoxy-4-methoxy-phenyl)-acryloyl]-4-hydroxy-2-methyl-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester

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Technology Process of (S)-8-Bromomethyl-6-[(E)-3-(3-tert-butoxycarbonylmethoxy-4-methoxy-phenyl)-acryloyl]-4-hydroxy-2-methyl-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester

There total 3 articles about (S)-8-Bromomethyl-6-[(E)-3-(3-tert-butoxycarbonylmethoxy-4-methoxy-phenyl)-acryloyl]-4-hydroxy-2-methyl-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186760-15-6
C₃₀H₃₂N₂O₈

: 1026035-80-2
(S)-8-Bromomethyl-6-[(E)-3-(3-tert-butoxycarbonylmethoxy-4-methoxy-phenyl)-acryloyl]-4-hydroxy-2-methyl-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester

Guidance literature:: With hydrogen bromide; In acetonitrile; for 1h; Ambient temperature;
DOI:10.1021/jm9606094

Reference yield:

: 153925-97-4,134106-68-6
3-methoxycarbonyl-2-methylduocarmycin A

: 1026035-80-2
(S)-8-Bromomethyl-6-[(E)-3-(3-tert-butoxycarbonylmethoxy-4-methoxy-phenyl)-acryloyl]-4-hydroxy-2-methyl-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / MeONa, MeOH / 3 h / Ambient temperature

2: 1.) NaH / 1.) DMF, -50 deg C, 2 h, 2.) DMF, -50 deg C, 2 h

3: 48percent aq. HBr / acetonitrile / 1 h / Ambient temperature

With methanol; hydrogen bromide; sodium methylate; sodium hydride; In acetonitrile;
DOI:10.1021/jm9606094

Reference yield:

: 186760-22-5
CPI

: 1026035-80-2
(S)-8-Bromomethyl-6-[(E)-3-(3-tert-butoxycarbonylmethoxy-4-methoxy-phenyl)-acryloyl]-4-hydroxy-2-methyl-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, -50 deg C, 2 h, 2.) DMF, -50 deg C, 2 h

2: 48percent aq. HBr / acetonitrile / 1 h / Ambient temperature

With hydrogen bromide; sodium hydride; In acetonitrile;
DOI:10.1021/jm9606094