N-((3S,4R,5S)-1-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl)acetamide

Base Information

Chemical Name:N-((3S,4R,5S)-1-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl)acetamide
CAS No.:868522-73-0
Molecular Formula:C₁₄H₂₀N₂O₃
Molecular Weight:264.324
Hs Code.:

Synonyms:N-((3S,4R,5S)-1-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl)acetamide

Suppliers and Price of N-((3S,4R,5S)-1-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((3S,4R,5S)-1-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl)acetamide

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Technology Process of N-((3S,4R,5S)-1-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl)acetamide

There total 18 articles about N-((3S,4R,5S)-1-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 944329-23-1
C₁₈H₂₄N₂O₅

: 868522-73-0
N-((3S,4R,5S)-1-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl)acetamide

Guidance literature:: With sodium methylate; In methanol;
DOI:10.1016/j.tetlet.2007.04.041

Reference yield: 35.0%

: 944329-22-0
(2S,3R,4S)-4-amino-1-benzyl-2-(hydroxymethyl)pyrrolidin-3-ol

: 108-24-7
acetic anhydride

: 868522-73-0
N-((3S,4R,5S)-1-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl)acetamide

Guidance literature:: In methanol;

Reference yield:

: 944329-21-9
C₁₂H₁₆N₄O₂

: 868522-73-0
N-((3S,4R,5S)-1-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / H₂ / Pd/C / tetrahydrofuran

2: 75 percent / pyridine

3: 96 percent / MeONa / methanol

With pyridine; hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetlet.2007.04.041