C₅₄H₅₂N₂O₉S₁₆

Base Information

• Chemical Name: C₅₄H₅₂N₂O₉S₁₆
• CAS No.: 207306-05-6
• Molecular Formula: C₅₄H₅₂N₂O₉S₁₆
• Molecular Weight: 1386.07
• Mol file: 207306-05-6.mol

Synonyms:C₅₄H₅₂N₂O₉S₁₆

Chemical Property of C₅₄H₅₂N₂O₉S₁₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₄H₅₂N₂O₉S₁₆

There total 9 articles about C₅₄H₅₂N₂O₉S₁₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(S)-2-Amino-succinic acid 4-{2-[2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-5-methylsulfanyl-[1,3]dithiol-4-ylsulfanyl]-ethyl} ester 1-(1-methyl-1-phenyl-ethyl) ester (207306-01-2) + (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinic acid 4-{2-[2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-5-methylsulfanyl-[1,3]dithiol-4-ylsulfanyl]-ethyl} ester (207306-03-4) → C54H52N2O9S16 (207306-05-6)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1039/a800759d

Reference yield:

(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinic acid 4-allyl ester 1-(1-methyl-1-phenyl-ethyl) ester (207305-92-8) → C54H52N2O9S16 (207306-05-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / N-methylmorpholine, glacial acetic acid / Pd(PPh₃)4 / CHCl₃ / Ambient temperature

2: 76 percent / diisopropyl azodicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

3: 92 percent / piperidine / tetrahydrofuran / 0.05 h / Ambient temperature

4: 87 percent / DIPEA, pyBOP / dimethylformamide / Ambient temperature

With piperidine; 4-methyl-morpholine; di-isopropyl azodicarboxylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

DOI:10.1039/a800759d

Reference yield:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → C54H52N2O9S16 (207306-05-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 87 percent / Na₂CO₃ / H₂O; dioxane / Ambient temperature

2: 97 percent / cyclohexane; CH₂Cl₂ / Ambient temperature

3: 82 percent / N-methylmorpholine, glacial acetic acid / Pd(PPh₃)4 / CHCl₃ / Ambient temperature

4: 76 percent / diisopropyl azodicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

5: 87 percent / TFA / CH₂Cl₂ / 0.08 h

6: 87 percent / DIPEA, pyBOP / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; di-isopropyl azodicarboxylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; cyclohexane; water; N,N-dimethyl-formamide;

DOI:10.1039/a800759d

upstream raw materials:

(S)-2-Amino-succinic acid 4-{2-[2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-5-methylsulfanyl-[1,3]dithiol-4-ylsulfanyl]-ethyl} ester 1-(1-methyl-1-phenyl-ethyl) ester

(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinic acid 4-{2-[2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-5-methylsulfanyl-[1,3]dithiol-4-ylsulfanyl]-ethyl} ester

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester

Refernces