(R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentanoic acid methyl ester

Base Information

Chemical Name:(R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentanoic acid methyl ester
CAS No.:176900-64-4
Molecular Formula:C₂₄H₃₂O₃Si
Molecular Weight:396.602
Hs Code.:

Synonyms:(R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentanoic acid methyl ester

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Chemical Property of (R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentanoic acid methyl ester

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Technology Process of (R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentanoic acid methyl ester

There total 6 articles about (R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2121-69-9
2,4-dimethylpentane-1,5-diol

: 176900-64-4
(R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / tetrahydrofuran; H₂O / 8 h / 28 °C / porcine pancreatic lipase

2: 98 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

3: 95 percent / aq. K₂CO₃ / methanol / 2 h / 40 °C

4: Jones reagent / acetone / 0.5 h / 0 °C

5: aq. NaOH / diethyl ether / 0.5 h / 0 °C

6: 1.) LDA, 2.) PhSeBr, 3.) 30percent aq. H₂O₂, pyridine

With pyridine; 1H-imidazole; sodium hydroxide; jones reagent; Phenylselenyl bromide; dihydrogen peroxide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0968-0896(96)00014-4

Reference yield:

: 90270-02-3,97937-36-5
(2R,4S)-1-hydroxy-2,4-dimethylpentyl acetate

: 176900-64-4
(R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

2: 95 percent / aq. K₂CO₃ / methanol / 2 h / 40 °C

3: Jones reagent / acetone / 0.5 h / 0 °C

4: aq. NaOH / diethyl ether / 0.5 h / 0 °C

5: 1.) LDA, 2.) PhSeBr, 3.) 30percent aq. H₂O₂, pyridine

With pyridine; 1H-imidazole; sodium hydroxide; jones reagent; Phenylselenyl bromide; dihydrogen peroxide; potassium carbonate; lithium diisopropyl amide; In methanol; diethyl ether; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0968-0896(96)00014-4

Reference yield:

: (2S,4R)-5-{[tert-butyl(diphenyl)silyl]oxy}-2,4-dimethylpentan-1-ol

: 176900-64-4
(R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Jones reagent / acetone / 0.5 h / 0 °C

2: aq. NaOH / diethyl ether / 0.5 h / 0 °C

3: 1.) LDA, 2.) PhSeBr, 3.) 30percent aq. H₂O₂, pyridine

With pyridine; sodium hydroxide; jones reagent; Phenylselenyl bromide; dihydrogen peroxide; lithium diisopropyl amide; In diethyl ether; acetone;
DOI:10.1016/0968-0896(96)00014-4