methyl <2α,6β(S*)>-1-<3-<<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl><(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

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Chemical Name:methyl <2α,6β(S*)>-1-<3-<<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl><(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate
CAS No.:89596-61-2
Molecular Formula:C₄₃H₆₅N₃O₇SSi
Molecular Weight:796.157
Hs Code.:

methyl <2α,6β(S*)>-1-<3-<<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl><(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

Synonyms:methyl <2α,6β(S*)>-1-<3-<<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl><(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

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Chemical Property of methyl <2α,6β(S*)>-1-<3-<<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl><(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

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Technology Process of methyl <2α,6β(S*)>-1-<3-<<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl><(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

There total 18 articles about methyl <2α,6β(S*)>-1-<3-<<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl><(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 89578-70-1
methyl (2α,6β)-1,2,3,6-tetrahydro-6(S*)-<2-(tert-butyldimethylsiloxy)heptyl>-2-pyridineacetate

: 89578-73-4
N-<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl>-N-<3-<(trifluoromethylsulfonyl)oxy>propyl>-4-methylbenzenesulfonamide

: 89596-61-2
methyl <2α,6β(S*)>-1-<3-<<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl><(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 13h; Ambient temperature;
DOI:10.1021/ja00323a030

Reference yield:

: 13379-98-1
3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

: 89596-61-2
methyl <2α,6β(S*)>-1-<3-<<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl><(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / p-TsOH*H₂O / diethyl ether / 3 h

2: 1.) KH; 2.) HCl / 1.) DMF-mineral oil, 2.5 h, 50 deg C; 2.) MeOH, 1.5 h, RT

3: 95 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

4: 70 percent / diisopropylethylamine / CH₂Cl₂ / 13 h / Ambient temperature

With pyridine; hydrogenchloride; potassium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ja00323a030

Reference yield:

: 109774-82-5
4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide

: 89596-61-2
methyl <2α,6β(S*)>-1-<3-<<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl><(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridinacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) KH; 2.) HCl / 1.) DMF-mineral oil, 2.5 h, 50 deg C; 2.) MeOH, 1.5 h, RT

2: 95 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

3: 70 percent / diisopropylethylamine / CH₂Cl₂ / 13 h / Ambient temperature

With pyridine; hydrogenchloride; potassium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja00323a030