1-(2-(4-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropanecarboxamido)phenoxy)quinolin-7-yloxy)ethyl)cyclopropyl benzoate

Base Information

Chemical Name:1-(2-(4-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropanecarboxamido)phenoxy)quinolin-7-yloxy)ethyl)cyclopropyl benzoate
CAS No.:1245932-06-2
Molecular Formula:C₃₈H₃₂FN₃O₆
Molecular Weight:645.687
Hs Code.:

Synonyms:1-(2-(4-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropanecarboxamido)phenoxy)quinolin-7-yloxy)ethyl)cyclopropyl benzoate

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Chemical Property of 1-(2-(4-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropanecarboxamido)phenoxy)quinolin-7-yloxy)ethyl)cyclopropyl benzoate

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Technology Process of 1-(2-(4-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropanecarboxamido)phenoxy)quinolin-7-yloxy)ethyl)cyclopropyl benzoate

There total 6 articles about 1-(2-(4-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropanecarboxamido)phenoxy)quinolin-7-yloxy)ethyl)cyclopropyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1245932-05-1
2-(1-(benzoyloxy)cyclopropyl)ethyl methanesulfonate

: N-(3-fluoro-4-(7-hydroxyquinolin-4-yloxy)phenyl)-N-phenylcyclopropane-1,1-dicarboxamide

: 1245932-06-2
1-(2-(4-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropanecarboxamido)phenoxy)quinolin-7-yloxy)ethyl)cyclopropyl benzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield: 58.0%

: 1245932-06-2
1-(2-(4-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropanecarboxamido)phenoxy)quinolin-7-yloxy)ethyl)cyclopropyl benzoate

Guidance literature:

Reference yield:

: 1221443-25-9
1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-cyclopropanol

: 1245932-06-2
1-(2-(4-(2-fluoro-4-(1-(phenylcarbamoyl)cyclopropanecarboxamido)phenoxy)quinolin-7-yloxy)ethyl)cyclopropyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: pyridinium p-toluenesulfonate / methanol / 20 °C

3: triethylamine / dichloromethane / 2 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 50 °C

With dmap; pyridinium p-toluenesulfonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;