2-amino-3-cyano-5-<2-(3',4',5'-trimethoxyphenyl)ethyl>-4-methylthiophene

Base Information

Chemical Name:2-amino-3-cyano-5-<2-(3',4',5'-trimethoxyphenyl)ethyl>-4-methylthiophene
CAS No.:152093-95-3
Molecular Formula:C₁₇H₂₀N₂O₃S
Molecular Weight:332.423
Hs Code.:

Synonyms:2-amino-3-cyano-5-<2-(3',4',5'-trimethoxyphenyl)ethyl>-4-methylthiophene

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Chemical Property of 2-amino-3-cyano-5-<2-(3',4',5'-trimethoxyphenyl)ethyl>-4-methylthiophene

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Technology Process of 2-amino-3-cyano-5-<2-(3',4',5'-trimethoxyphenyl)ethyl>-4-methylthiophene

There total 4 articles about 2-amino-3-cyano-5-<2-(3',4',5'-trimethoxyphenyl)ethyl>-4-methylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 152093-89-5
5-(3,4,5-trimethoxyphenyl)-2-pentylidenemalononitrile

: 152093-95-3
2-amino-3-cyano-5-<2-(3',4',5'-trimethoxyphenyl)ethyl>-4-methylthiophene

Guidance literature:: With sulfur; diisopropylamine; In ethanol; for 1.5h; Heating;
DOI:10.1021/jm00073a009

Reference yield:

: 152093-83-9
5-(3,4,5-trimethoxyphenyl)-2-pentanone

: 152093-95-3
2-amino-3-cyano-5-<2-(3',4',5'-trimethoxyphenyl)ethyl>-4-methylthiophene

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / glacial AcOH, NH₄OAc / benzene / 2 h / Heating

2: 38 percent / sulfur, i-Pr₂NH / ethanol / 1.5 h / Heating

With ammonium acetate; sulfur; acetic acid; diisopropylamine; In ethanol; benzene;
DOI:10.1021/jm00073a009

Reference yield:

: 65495-26-3
5-(2-bromo-ethyl)-1,2,3-trimethoxy-benzene

: 152093-95-3
2-amino-3-cyano-5-<2-(3',4',5'-trimethoxyphenyl)ethyl>-4-methylthiophene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH, 2.) NaI / 1.) THF, DMSO, RT, 30 min, 2.) THF, DMSO, reflux, 24 h

2: 80 percent / aq. KOH / 3 h / 90 °C

3: 67 percent / glacial AcOH, NH₄OAc / benzene / 2 h / Heating

4: 38 percent / sulfur, i-Pr₂NH / ethanol / 1.5 h / Heating

With potassium hydroxide; ammonium acetate; sodium hydride; sulfur; acetic acid; diisopropylamine; sodium iodide; In ethanol; benzene;
DOI:10.1021/jm00073a009